{"id":"W1972829697","doi":"10.1208/s12248-012-9396-8","title":"Metrics for the Evaluation of Bioequivalence of Modified-Release Formulations","year":2012,"lang":"en","type":"review","venue":"The AAPS Journal","topic":"Drug Solubulity and Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Bioequivalence; Equivalence (formal languages); Mathematics; Immediate release; Dosage form; Pharmacokinetics; Pharmacology; Statistics; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.012934,0.0002312404,0.0007843807,0.0002083438,0.0004907923,0.00001973391,0.0007999333,0.0003571461,0.0002654385],"category_scores_gemma":[0.0006633043,0.0001183273,0.0007101135,0.0004875821,0.0002469124,0.000131196,0.00007725517,0.0009761413,0.00002323957],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001200059,"about_ca_system_score_gemma":0.0005525476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001108618,"about_ca_topic_score_gemma":0.000002822305,"domain_scores_codex":[0.9959379,0.001964948,0.001105955,0.0001211972,0.0005572783,0.0003127226],"domain_scores_gemma":[0.9928933,0.004070693,0.001746889,0.0003691613,0.0008074773,0.0001124846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003940294,0.000135897,0.000008038029,0.002376463,0.0008179114,3.426468e-7,0.0004194174,0.00187736,0.000004584358,0.002484343,0.001581596,0.9902546],"study_design_scores_gemma":[0.0006432678,0.00006616531,0.000009292311,0.0005887714,0.01554243,0.0001212382,0.00009618903,0.01243426,0.00003493498,0.001124531,0.9691902,0.0001486544],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000181621,0.9915962,0.002897683,0.0001049541,0.002635931,0.001582817,0.0002767191,0.00000705707,0.000717016],"genre_scores_gemma":[0.03756119,0.9611809,0.00006200484,0.00005477547,0.0007656719,0.00009795453,0.00002008493,0.00002236342,0.0002350592],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.990106,"threshold_uncertainty_score":0.4825247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.6842554227626768,"score_gpt":0.5713271265878597,"score_spread":0.1129282961748171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}