{"id":"W1972856271","doi":"10.1371/journal.pone.0015742","title":"The PTEN Phosphatase Controls Intestinal Epithelial Cell Polarity and Barrier Function: Role in Colorectal Cancer Progression","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institutes of Health Research; Université de Sherbrooke","funders":"Canadian Institutes of Health Research; Canadian Association of Gastroenterology; Crohn's and Colitis Foundation of Canada","keywords":"PTEN; Tensin; Cancer research; Cell migration; Small hairpin RNA; Biology; PI3K/AKT/mTOR pathway; Intestinal epithelium; Downregulation and upregulation; Cell biology; Cell; Signal transduction; Cell culture; Epithelium; Gene knockdown","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001444847,0.0004113692,0.0001922975,0.000402646,0.0002223398,0.0005796664,0.0002070031,0.000290937,0.001608826],"category_scores_gemma":[0.0001977951,0.0001120085,0.000189689,0.0003010276,0.0003567007,0.0003260476,0.0003439875,0.0003765165,0.0003584852],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003768597,"about_ca_system_score_gemma":0.0004561343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007548954,"about_ca_topic_score_gemma":0.0006229298,"domain_scores_codex":[0.9999139,0.00001051682,0.000004821753,0.00001623592,0.00002694305,0.00002754905],"domain_scores_gemma":[0.9998782,0.000008108444,0.0000492979,0.000005244439,0.00001909127,0.00004007448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006182345,0.0000575889,0.004252015,0.0004356158,0.00002944126,0.0005603143,0.00004485682,0.0005070062,0.9747224,0.001238366,0.0005343572,0.01699989],"study_design_scores_gemma":[0.0001351555,0.000974335,0.09343252,0.00007919146,0.0001836049,0.003516145,0.0002485847,0.005249631,0.8647807,0.001917851,0.02943815,0.0000441453],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9370758,0.04688554,0.006940285,0.001260708,0.0001406213,0.00008206732,0.0009021873,0.0004039205,0.006308775],"genre_scores_gemma":[0.9875106,0.008977585,0.0007952759,0.00006863219,0.00003089377,0.00001821879,0.0002238208,0.00001277509,0.002362281],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001608826,"threshold_uncertainty_score":0.005382061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008990669768626091,"score_gpt":0.2350056327806362,"score_spread":0.2260149630120101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}