{"id":"W1972902934","doi":"10.1016/j.ccr.2011.06.020","title":"Cell of Origin in AML: Susceptibility to MN1-Induced Transformation Is Regulated by the MEIS1/AbdB-like HOX Protein Complex","year":2011,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Terry Fox Research Institute; BC Cancer Agency","funders":"Deutsche Krebshilfe; Biotechnology and Biological Sciences Research Council; José Carreras Leukämie-Stiftung; Terry Fox Foundation; Deutsche Forschungsgemeinschaft; National Centre for the Replacement, Refinement and Reduction of Animals in Research; Canadian Institutes of Health Research; Cancer Research Society; European Hematology Association","keywords":"Hox gene; Biology; Chromatin; Transformation (genetics); Gene; Psychological repression; Cell biology; Genetics; Cancer research; Transcription factor; Computational biology; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000526845,0.0001969671,0.0003597611,0.00009234107,0.00005223319,0.000009230234,0.0003072157,0.0001490298,0.002146645],"category_scores_gemma":[0.00001575905,0.000144525,0.00008610883,0.0005372009,0.0001060137,0.0001242389,0.00004485593,0.0003691468,0.00006986464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008480622,"about_ca_system_score_gemma":0.000450623,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01262366,"about_ca_topic_score_gemma":0.001156641,"domain_scores_codex":[0.9981859,0.0001341734,0.0004761604,0.0003504954,0.0004254469,0.0004278031],"domain_scores_gemma":[0.9988321,0.00003258053,0.0001085428,0.0006345091,0.00020812,0.000184155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008520861,0.0002561885,0.001804119,0.0004275679,0.0000227093,0.000004802731,0.01122456,0.000004462269,0.9585736,0.00001842931,0.02315422,0.003657278],"study_design_scores_gemma":[0.002931828,0.0004523808,0.01181755,0.00009422623,0.00003734529,0.000001828511,0.00109282,0.0007269832,0.9670265,0.00004147877,0.01559219,0.0001848642],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820641,0.0002192728,0.0001200015,0.001278551,0.00006319453,0.002372066,0.00006413079,0.00003751454,0.01378115],"genre_scores_gemma":[0.9960551,0.00005476755,0.0003460368,0.0006291661,0.00004145887,0.0001905539,0.00003972714,0.00003367427,0.002609537],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01399096,"threshold_uncertainty_score":0.9987655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07163301436425436,"score_gpt":0.3197919472549218,"score_spread":0.2481589328906675,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}