{"id":"W1972902934","doi":"10.1016/j.ccr.2011.06.020","title":"Cell of Origin in AML: Susceptibility to MN1-Induced Transformation Is Regulated by the MEIS1/AbdB-like HOX Protein Complex","year":2011,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Terry Fox Research Institute; BC Cancer Agency","funders":"Deutsche Krebshilfe; Biotechnology and Biological Sciences Research Council; José Carreras Leukämie-Stiftung; Terry Fox Foundation; Deutsche Forschungsgemeinschaft; National Centre for the Replacement, Refinement and Reduction of Animals in Research; Canadian Institutes of Health Research; Cancer Research Society; European Hematology Association","keywords":"Hox gene; Biology; Chromatin; Transformation (genetics); Gene; Psychological repression; Cell biology; Genetics; Cancer research; Transcription factor; Computational biology; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001742101,0.0001915368,0.000406963,0.0005819752,0.0004024902,0.0006271913,0.0001972702,0.0003359953,0.005599096],"category_scores_gemma":[0.0002693736,0.0002104024,0.0002117188,0.0002692575,0.0002905922,0.0002412017,0.0004609098,0.0007385513,0.001221327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003716357,"about_ca_system_score_gemma":0.0001842286,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00122729,"about_ca_topic_score_gemma":0.001549635,"domain_scores_codex":[0.9997609,0.00003524523,0.00002225381,0.00003704491,0.00006485831,0.00007967747],"domain_scores_gemma":[0.9997434,0.00005264113,0.00004464677,0.00004765214,0.00002598197,0.00008564862],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006169428,0.00009693261,0.003740786,0.00001626141,0.000009268795,0.0001867705,0.00008212336,0.00006240428,0.9923074,0.0004866031,0.0001440327,0.002250531],"study_design_scores_gemma":[0.0001022147,0.0008034063,0.1023848,0.00001020871,0.00008300375,0.005439858,0.0005248376,0.00232114,0.8783859,0.0006107087,0.009314279,0.00001964656],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967802,0.0004676592,0.000735819,0.00007662662,0.00001033091,0.00002352166,0.0002911811,0.00004894114,0.001565799],"genre_scores_gemma":[0.9978036,0.0001149593,0.0002024596,0.00002062321,0.000003181338,0.00001037844,0.0003427626,0.00001420766,0.001487654],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005599096,"threshold_uncertainty_score":0.01873082,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07163301436425436,"score_gpt":0.3197919472549218,"score_spread":0.2481589328906675,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}