{"id":"W1972915658","doi":"10.2174/1874091x01206010031","title":"Effects of Nerve Growth Factor and Nitric Oxide Synthase Inhibitors on Amyloid Precursor Protein mRNA Levels and Protein Stability","year":2012,"lang":"en","type":"article","venue":"The Open Biochemistry Journal","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Nerve growth factor; Cycloheximide; Nitric oxide synthase; Amyloid precursor protein; Nitric oxide; Messenger RNA; Internal medicine; Chemistry; Endocrinology; Biology; Protein biosynthesis; Biochemistry; Medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005444763,0.0002175168,0.0003146789,0.0000423288,0.0001988124,0.00008930737,0.0001948002,0.00008575603,0.00007848877],"category_scores_gemma":[0.0005371681,0.0001282043,0.00007391041,0.0001268395,0.0002340078,0.0001963969,0.0001997509,0.0004041905,0.000005023844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009411744,"about_ca_system_score_gemma":0.0002263518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004950115,"about_ca_topic_score_gemma":2.233202e-7,"domain_scores_codex":[0.9985238,0.0001796105,0.0002675382,0.0002132499,0.0004255397,0.0003902941],"domain_scores_gemma":[0.9985831,0.0001359332,0.0001998193,0.0002511226,0.0001277085,0.000702302],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001814206,0.001307863,0.03350101,0.0008052999,0.001429799,0.00007590873,0.0001383297,1.371516e-8,0.9594104,0.000009908505,0.0001001524,0.001407153],"study_design_scores_gemma":[0.002314579,0.0002867899,0.07372753,0.0005941817,0.0001917071,0.000168752,0.00008635825,0.000001469778,0.9223772,0.0001299053,0.000006966452,0.0001145532],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924447,0.004880144,0.000002397609,0.0002976614,0.00001186187,0.001978802,0.00006265492,0.000007893973,0.0003139009],"genre_scores_gemma":[0.9994265,0.00003455945,0.0001800845,0.0000158065,0.0001272408,0.00009731799,0.000004802309,0.00002009154,0.00009362897],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04022652,"threshold_uncertainty_score":0.5228019,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03086746599788638,"score_gpt":0.3012869205148943,"score_spread":0.2704194545170079,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}