{"id":"W197294569","doi":"10.1016/j.pharmthera.2014.03.007","title":"Epigenetic targets and drug discovery","year":2014,"lang":"en","type":"review","venue":"Pharmacology & Therapeutics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Structural Genomics Consortium","funders":"Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Wellcome Trust; Ontario Ministry of Economic Development and Innovation; Ontario Genomics Institute; Canadian Institutes of Health Research; Genome Canada","keywords":"Epigenetics; Histone; Methyltransferase; Drug discovery; Chromatin; Methylation; Histone methyltransferase; Acetylation; Computational biology; EZH2; Biology; Histone-modifying enzymes; Chemical biology; Histone methylation; DNA methylation; Genetics; Bioinformatics; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003642951,0.0004959539,0.0008873531,0.00009895558,0.000122792,0.00005132474,0.0003208334,0.0004608659,0.00002508805],"category_scores_gemma":[0.000006219079,0.0004334442,0.0002819277,0.00009437287,0.000196147,0.00000385779,0.000224812,0.0003050508,0.00002650097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002371032,"about_ca_system_score_gemma":0.0001593602,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003208291,"about_ca_topic_score_gemma":0.00000568291,"domain_scores_codex":[0.9978399,0.0004959684,0.000488901,0.0006527394,0.0001203947,0.0004020621],"domain_scores_gemma":[0.9990469,0.0001024939,0.0003125326,0.000364539,0.00005816813,0.0001154185],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002256628,0.00009930249,0.00003925426,0.002380547,0.001173892,0.000004910637,0.00004075882,0.000009339922,0.01110488,0.00002753426,0.0008668008,0.9842302],"study_design_scores_gemma":[0.0002914073,0.0001292232,0.000007063942,0.0001465021,0.002072588,0.000008721326,0.000003099254,0.00001346046,0.005471596,0.0000959952,0.991312,0.0004483579],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006239236,0.9962994,0.00122787,0.00008297058,0.0009040982,0.0005570396,0.00004550167,0.00001756544,0.0002416327],"genre_scores_gemma":[0.0008809004,0.9954222,0.0002364812,0.0008373634,0.000919664,0.00009972302,0.0003169048,0.0001057127,0.001181038],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9904452,"threshold_uncertainty_score":0.9998117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03393759567537,"score_gpt":0.3629949173679335,"score_spread":0.3290573216925635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}