{"id":"W197294569","doi":"10.1016/j.pharmthera.2014.03.007","title":"Epigenetic targets and drug discovery","year":2014,"lang":"en","type":"review","venue":"Pharmacology & Therapeutics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Structural Genomics Consortium","funders":"Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Wellcome Trust; Ontario Ministry of Economic Development and Innovation; Ontario Genomics Institute; Canadian Institutes of Health Research; Genome Canada","keywords":"Epigenetics; Histone; Methyltransferase; Drug discovery; Chromatin; Methylation; Histone methyltransferase; Acetylation; Computational biology; EZH2; Biology; Histone-modifying enzymes; Chemical biology; Histone methylation; DNA methylation; Genetics; Bioinformatics; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009279113,0.001228203,0.001735269,0.001975643,0.0003777308,0.001368798,0.001187655,0.001420356,0.005705956],"category_scores_gemma":[0.0009142269,0.000444566,0.0004731216,0.002197297,0.0009857316,0.001683582,0.001306574,0.003122648,0.003238366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000951493,"about_ca_system_score_gemma":0.001318629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007658219,"about_ca_topic_score_gemma":0.002393965,"domain_scores_codex":[0.9997223,0.00005658162,0.00002432143,0.0000435398,0.0001168065,0.00003647203],"domain_scores_gemma":[0.999755,0.0001133625,0.00003087293,0.00001393146,0.00005721726,0.00002967572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008500556,0.00008141527,0.0001142522,0.006098174,0.00008551684,0.000204295,0.00003728494,0.0006260801,0.002385289,0.01153309,0.08137235,0.8973773],"study_design_scores_gemma":[0.0000209731,0.0000452318,0.0002174315,0.0009040206,0.00004982811,0.0004071002,0.00002298654,0.0001315558,0.0004762748,0.004550442,0.9931624,0.00001171571],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009980789,0.9948937,0.0006566623,0.000819472,0.0008347362,0.00001026701,0.00002909793,0.000021884,0.002634353],"genre_scores_gemma":[0.0009528811,0.9941782,0.0005291782,0.0007203144,0.0007549723,0.00001766444,0.00005443434,0.000003605981,0.002788862],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005705956,"threshold_uncertainty_score":0.01908833,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03393759567537,"score_gpt":0.3629949173679335,"score_spread":0.3290573216925635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}