{"id":"W1972974215","doi":"10.1016/j.toxicon.2008.03.015","title":"Attenuation of maitotoxin-induced cytotoxicity in rat aortic smooth muscle cells by inhibitors of Na+/Ca2+ exchange, and calpain activation","year":2008,"lang":"en","type":"article","venue":"Toxicon","topic":"Marine Toxins and Detection Methods","field":"Environmental Science","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"Defence Research and Development Canada","funders":"","keywords":"Calpain; Extracellular; Chemistry; Cytosol; Cytotoxicity; Sodium-calcium exchanger; Intracellular; Pharmacology; Efflux; Fura-2; Viability assay; Marine toxin; In vitro; Biochemistry; Biophysics; Toxin; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005055847,0.0001237865,0.0002090075,0.0000897019,0.00005358183,0.000004153164,0.00006932361,0.0001036153,0.0004290902],"category_scores_gemma":[0.00007731314,0.0001222745,0.00003731476,0.0003407203,0.0001202848,0.0001910002,0.00008212485,0.0001143883,0.000006946388],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000108307,"about_ca_system_score_gemma":0.00001169545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001228547,"about_ca_topic_score_gemma":0.0001170943,"domain_scores_codex":[0.9987869,0.0001781616,0.0003575967,0.0002522387,0.0002584686,0.0001665957],"domain_scores_gemma":[0.9994397,0.00009491594,0.000207988,0.0001800176,0.000009788684,0.00006756558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002525577,0.0001033948,0.01612473,0.00002191271,0.000001619336,7.215166e-7,0.0003436626,0.00006518154,0.9573835,0.000002422822,0.0002431564,0.02568451],"study_design_scores_gemma":[0.0004195606,0.0001389159,0.1414972,0.00001392811,0.000003087049,7.680019e-7,0.00005123347,0.001330375,0.8561292,0.00004379137,0.0002639133,0.0001080806],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971728,0.000009676442,0.001221479,0.00004109587,0.00007114962,0.0002923559,0.000004650212,0.00001669114,0.001170153],"genre_scores_gemma":[0.9985415,0.00003049302,0.001104838,0.00004919964,0.00001962254,0.00001566065,0.000003208434,0.00001147913,0.0002239786],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1253725,"threshold_uncertainty_score":0.4986209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01765105664342905,"score_gpt":0.2464204856480372,"score_spread":0.2287694290046081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}