{"id":"W1972984111","doi":"10.1186/1742-4690-5-44","title":"Optimization of the doxycycline-dependent simian immunodeficiency virus through in vitro evolution","year":2008,"lang":"en","type":"article","venue":"Retrovirology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Medical Research Council; McGill University; National Cancer Institute; Aids Fonds; National Institutes of Health; International AIDS Vaccine Initiative; U.S. Department of Health and Human Services","keywords":"Simian immunodeficiency virus; Virology; Doxycycline; Biology; Virus; Attenuated vaccine; Viral replication; Genetics; Gene; Virulence; Antibiotics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003726169,0.0006069422,0.0003295317,0.0002037509,0.0001846426,0.0004460474,0.0005799982,0.0003506393,0.0008399584],"category_scores_gemma":[0.0004347749,0.0001738721,0.0003159465,0.0002467748,0.0002115838,0.0002011382,0.0003588093,0.0006921927,0.0003879246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004147775,"about_ca_system_score_gemma":0.0002829258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007594465,"about_ca_topic_score_gemma":0.001342925,"domain_scores_codex":[0.9996694,0.00008478502,0.00005344958,0.00005359265,0.00009064186,0.00004801362],"domain_scores_gemma":[0.9997254,0.00007271679,0.00008861831,0.00003970062,0.00004047418,0.00003297322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008296893,0.00009225854,0.0003860865,0.00007876998,0.00001448927,0.00005216069,0.00002759315,0.001231503,0.9951945,0.0001320497,0.00005353144,0.002654149],"study_design_scores_gemma":[0.00001269529,0.000367058,0.0008971135,0.000009877429,0.00003258515,0.0001435977,0.00001457061,0.002828013,0.9924345,0.00002807511,0.003222828,0.000009238202],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9765434,0.001295992,0.01868217,0.00009814616,0.00004632048,0.0002656064,0.0005875941,0.0001685356,0.002312364],"genre_scores_gemma":[0.9587899,0.001311231,0.03516826,0.00007657271,0.00001196966,0.0002516728,0.00144794,0.0001155082,0.002826905],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008399584,"threshold_uncertainty_score":0.003009439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01433988658774851,"score_gpt":0.2438695994195253,"score_spread":0.2295297128317768,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}