{"id":"W1972987163","doi":"10.1158/1538-7445.fbcr13-ia7","title":"Abstract IA7: Translational control of cancer via eIF4E/4E-BPs","year":2013,"lang":"en","type":"article","venue":"Cancer Research","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"EIF4E; mTORC1; PI3K/AKT/mTOR pathway; Cancer research; Biology; PTEN; Cancer; Phosphorylation; Translation (biology); P70-S6 Kinase 1; Mechanistic target of rapamycin; Cell growth; Initiation factor; Cell biology; Signal transduction; Genetics; Messenger RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001463772,0.0005196265,0.0002930486,0.0004170358,0.0003023378,0.0004128813,0.0002640764,0.0003522683,0.004370149],"category_scores_gemma":[0.0001282687,0.0001381808,0.0003496512,0.0002578847,0.0002012404,0.000189386,0.000321941,0.0007296202,0.002401822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003986765,"about_ca_system_score_gemma":0.000258111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003085727,"about_ca_topic_score_gemma":0.0002356046,"domain_scores_codex":[0.9998946,0.00001234431,0.00001042272,0.00002403489,0.00003163807,0.00002706168],"domain_scores_gemma":[0.9999273,0.000007267388,0.00002113504,0.000007642962,0.00001389045,0.00002273864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005818806,0.00007453998,0.0004351705,0.0002541714,0.00001886444,0.0002943416,0.00001938977,0.0003773117,0.9794136,0.00218279,0.002671464,0.01367645],"study_design_scores_gemma":[0.00009933391,0.0004686185,0.006379864,0.00003602628,0.00003658105,0.000640183,0.00003102391,0.001500673,0.9361009,0.0009525988,0.05373539,0.00001882004],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.8820144,0.03078553,0.02173276,0.003128299,0.00215773,0.0002855217,0.007308464,0.002191925,0.05039538],"genre_scores_gemma":[0.955928,0.006060711,0.006397435,0.0004188482,0.000244356,0.0001289864,0.006220127,0.0001526722,0.02444897],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.004370149,"threshold_uncertainty_score":0.01461959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04372067828464899,"score_gpt":0.3939833166977745,"score_spread":0.3502626384131255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}