{"id":"W1973012722","doi":"10.1002/bdra.20479","title":"Frequency of holoprosencephaly in the International Clearinghouse Birth Defects Surveillance Systems: Searching for population variations","year":2008,"lang":"en","type":"article","venue":"Birth Defects Research Part A Clinical and Molecular Teratology","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Health Services","funders":"U.S. Public Health Service","keywords":"Holoprosencephaly; Hydranencephaly; Epidemiology; Demography; Population; Etiology; Medicine; Pediatrics; Pregnancy; Biology; Environmental health; Fetus; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003051225,0.0001486519,0.0003322116,0.0001425074,0.0002422498,0.00003768758,0.0003564032,0.0002037388,0.000001919035],"category_scores_gemma":[0.003970165,0.0001170592,0.0001277178,0.0002514188,0.0004456705,0.000009079562,0.000202519,0.0003343397,0.000002808907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001093248,"about_ca_system_score_gemma":0.0001557366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001465983,"about_ca_topic_score_gemma":0.0002563039,"domain_scores_codex":[0.9968051,0.001300402,0.0005840932,0.0005342187,0.0003480857,0.0004281556],"domain_scores_gemma":[0.998319,0.0007604397,0.0001234194,0.0003648368,0.0003460502,0.00008624457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001572365,0.0002264751,0.9436873,0.0001244132,0.0001120724,0.00008503722,0.0002199124,0.0001251435,0.04954557,0.004962589,0.0003642677,0.000390007],"study_design_scores_gemma":[0.005107178,0.002838202,0.95192,0.0002044917,0.00002822492,0.0003454761,0.000376893,0.001953098,0.01095805,0.002793928,0.02275881,0.0007156257],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995586,0.001366439,0.001634233,0.0002432277,0.00020966,0.0007351458,0.000047154,0.00001259035,0.0001655233],"genre_scores_gemma":[0.9981056,0.0007423466,0.0004532894,0.0001848047,0.0001653609,0.0002035502,0.00007840709,0.00002160226,0.00004507658],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03858752,"threshold_uncertainty_score":0.4773534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09855791477742888,"score_gpt":0.3955752736103808,"score_spread":0.2970173588329519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}