{"id":"W1973032438","doi":"10.1371/journal.pone.0020362","title":"Transcriptional and Post-Transcriptional Mechanisms for Oncogenic Overexpression of Ether À Go-Go K+ Channel","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Canadian Institutes of Health Research; Ministry of Education of the People's Republic of China","keywords":"Gene knockdown; Gene silencing; E2F1; Transactivation; Downregulation and upregulation; EGR1; Biology; RNA interference; Carcinogenesis; Transcriptional regulation; Cell growth; Molecular biology; Cell biology; Regulation of gene expression; Cancer research; Gene expression; Gene; Biochemistry; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001078214,0.000104255,0.0001194934,0.0000446415,0.00005568003,0.000004541834,0.0000575932,0.0001557064,0.0001793707],"category_scores_gemma":[0.00002139978,0.00009945596,0.00008340203,0.00003075475,0.00004443745,0.000008169292,0.00001368398,0.0000426811,0.00000433178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008308462,"about_ca_system_score_gemma":0.0000270958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006551243,"about_ca_topic_score_gemma":0.000003371176,"domain_scores_codex":[0.9993087,0.00002405778,0.0001676624,0.000216706,0.0001593339,0.0001235078],"domain_scores_gemma":[0.9995757,0.000006681169,0.00006183327,0.0001081583,0.0001903984,0.00005723163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005900765,0.0004539655,0.00003103305,0.00006557743,0.0001092052,6.996407e-8,0.0001990491,0.00000393831,0.9915931,0.006732168,0.00008298349,0.0001388409],"study_design_scores_gemma":[0.001119178,0.0006874033,0.00317578,0.00006042803,0.00006544752,0.000003108024,0.00008222803,0.0005352761,0.9894728,0.003856634,0.0007957122,0.0001459771],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9526204,0.0004311892,0.04535228,0.0001853214,0.0001653782,0.0004259272,0.0002145289,0.00001693317,0.0005880442],"genre_scores_gemma":[0.9907099,0.00005973286,0.006971837,0.0001897807,0.0002008506,0.00005725218,0.0002800032,0.00002086983,0.001509794],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03838045,"threshold_uncertainty_score":0.4055696,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05466073017369657,"score_gpt":0.227093933727991,"score_spread":0.1724332035542944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}