{"id":"W1973068164","doi":"10.1016/j.bbamem.2005.02.004","title":"Agonist-induced up-regulation of human somatostatin receptor type 1 is regulated by β-arrestin-1 and requires an essential serine residue in the receptor C-tail","year":2005,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Biomembranes","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Royal Victoria Hospital","funders":"","keywords":"Internalization; Somatostatin receptor; Receptor; Agonist; 5-HT5A receptor; G protein-coupled receptor; Biology; Enzyme-linked receptor; Forskolin; Cell biology; G protein-coupled receptor kinase; Somatostatin; Arrestin; Mutant; Beta adrenergic receptor kinase; Somatostatin receptor 2; Somatostatin receptor 1; Serine; Biochemistry; Phosphorylation; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008380658,0.000258368,0.0001844339,0.0001545388,0.0001497109,0.0003061768,0.0001098388,0.0001756724,0.001491361],"category_scores_gemma":[0.000124692,0.0001513507,0.0002822328,0.0001106278,0.0001395557,0.0001406844,0.0001674585,0.0004636929,0.0006727778],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000398308,"about_ca_system_score_gemma":0.0001712992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005155369,"about_ca_topic_score_gemma":0.001390449,"domain_scores_codex":[0.9998837,0.00001715574,0.000009457137,0.00001765808,0.00002064841,0.00005149453],"domain_scores_gemma":[0.9999117,0.0000216725,0.00002236176,0.00001261277,0.000008551256,0.00002300878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002512139,0.00002006533,0.0001410466,0.00001869795,0.000004652979,0.0001075115,0.000007648146,0.00002685875,0.9986884,0.00006909238,0.00006371059,0.0006011009],"study_design_scores_gemma":[0.00003785913,0.0001756746,0.01591082,0.000008523744,0.00001364392,0.0004587397,0.00003540438,0.0005219913,0.9804155,0.00005062504,0.002365212,0.000005946063],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951657,0.002047136,0.0004377585,0.0001331402,0.00004317979,0.00002056137,0.0005653265,0.00003770276,0.001549598],"genre_scores_gemma":[0.9939777,0.001171351,0.0004809835,0.0001136744,0.00001462938,0.00002817048,0.001348954,0.00001761491,0.00284697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001491361,"threshold_uncertainty_score":0.004989147,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01429365005136081,"score_gpt":0.2747018545989353,"score_spread":0.2604082045475745,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}