{"id":"W1973094863","doi":"10.1074/jbc.m502264200","title":"Proprotein Covertases Are Responsible for Proteolysis and Inactivation of Endothelial Lipase","year":2005,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Diabetes, Cardiovascular Risks, and Lipoproteins","field":"Medicine","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"National Heart, Lung, and Blood Institute","keywords":"Lipoprotein lipase; Proprotein Convertases; Furin; Proprotein convertase; Proteolysis; Biochemistry; Proteases; Biology; Cleavage (geology); Lipase; Cleave; Enzyme; Lipoprotein; LDL receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002392761,0.0004126171,0.0002007825,0.0002198548,0.0001538337,0.0003009737,0.0001994587,0.0002891002,0.0009012836],"category_scores_gemma":[0.0002499204,0.0001934829,0.0004363833,0.0001694846,0.0002297213,0.0002362919,0.0001924153,0.0007266014,0.0004681478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002974019,"about_ca_system_score_gemma":0.0002081064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004431473,"about_ca_topic_score_gemma":0.0002993634,"domain_scores_codex":[0.9997975,0.00003232238,0.00002471771,0.00004918221,0.00005869691,0.00003772435],"domain_scores_gemma":[0.9998499,0.00002267798,0.00005737439,0.00001572495,0.00002528947,0.0000290731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008579078,0.00001107316,0.0003953778,0.0000554309,0.00001309886,0.0002314037,0.000009302776,0.00004458027,0.996909,0.0001099031,0.00005323498,0.002081875],"study_design_scores_gemma":[0.00001953661,0.00008805374,0.008318014,0.000008663606,0.00002373153,0.001553516,0.00003266158,0.0006661672,0.9850772,0.0001754534,0.004031355,0.000005731835],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.940348,0.021286,0.03255514,0.0006956441,0.0001771979,0.0001224499,0.0008212955,0.000191638,0.003802472],"genre_scores_gemma":[0.9780106,0.006232391,0.009053722,0.0002151938,0.00003600281,0.00006081437,0.0008502176,0.00003001803,0.00551116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009012836,"threshold_uncertainty_score":0.003015101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02412047161201392,"score_gpt":0.2631958984770497,"score_spread":0.2390754268650358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}