{"id":"W1973121454","doi":"10.1021/pr401106h","title":"Metabolomic Profiling Identifies Biochemical Pathways Associated with Castration-Resistant Prostate Cancer","year":2013,"lang":"en","type":"article","venue":"Journal of Proteome Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Genome British Columbia","funders":"National Cancer Institute","keywords":"Prostate cancer; Metabolomics; In silico; Computational biology; Biological pathway; Metabolic pathway; Biology; Cancer research; Cancer; Bioinformatics; Gene; Medicine; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002019826,0.0001740327,0.000456124,0.0005235286,0.0002171698,0.000194961,0.0002048298,0.0001186438,0.0003314871],"category_scores_gemma":[0.0006041162,0.0001019167,0.0001202702,0.0008034959,0.0003475268,0.0003940759,0.0000687947,0.001144947,0.00003703466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005877487,"about_ca_system_score_gemma":0.001973068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001833605,"about_ca_topic_score_gemma":0.00001474233,"domain_scores_codex":[0.9963813,0.0002574539,0.0005505302,0.0002508539,0.001857391,0.0007024193],"domain_scores_gemma":[0.9956578,0.000172072,0.0002583329,0.0002133054,0.003320757,0.0003777316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001797236,0.0003087384,0.008195953,0.0002095859,0.0004773129,0.0003092155,0.0003896882,0.000004511053,0.9855812,0.00002533658,0.001957017,0.0007442064],"study_design_scores_gemma":[0.005085234,0.002459045,0.05093009,0.00113766,0.0001159153,0.0001283653,0.001421361,0.0001261897,0.9373963,0.000839601,0.0001708965,0.0001892736],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901779,0.004197116,0.000009548323,0.003077592,0.00006015509,0.002178452,0.00002077015,0.00001758549,0.000260936],"genre_scores_gemma":[0.9946854,0.0006974168,0.0008153657,0.00001661045,0.0002323217,0.0004401311,0.00001741784,0.00003694529,0.003058431],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04818483,"threshold_uncertainty_score":0.4974287,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08383057731042572,"score_gpt":0.3788156664233696,"score_spread":0.2949850891129439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}