{"id":"W1973130152","doi":"10.1111/cbdd.12475","title":"The Unique Binding Mode of Laulimalide to Two Tubulin Protofilaments","year":2014,"lang":"en","type":"article","venue":"Chemical Biology & Drug Design","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Allard Foundation; Alberta Cancer Foundation","keywords":"Tubulin; Microtubule; Chemistry; Plasma protein binding; Biophysics; Binding site; Molecular dynamics; Computational biology; Biology; Cell biology; Biochemistry; Computational chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004082296,0.0001886565,0.0002061351,0.00005579695,0.000298831,0.0002752067,0.0003658557,0.0002888616,0.001396625],"category_scores_gemma":[0.0001040626,0.0001337869,0.0002612107,0.00006300992,0.0002942302,0.0003164052,0.0002237462,0.000396541,0.0001288005],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004149412,"about_ca_system_score_gemma":0.0004755931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006183817,"about_ca_topic_score_gemma":0.007465525,"domain_scores_codex":[0.9999686,0.00000397828,0.000001342844,0.000009621552,0.000006865008,0.000009572348],"domain_scores_gemma":[0.9999717,0.000005949795,0.000006351064,0.000003136254,0.000002737243,0.00001013675],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005360136,0.0003149917,0.006669058,0.0002775213,0.0001409687,0.0008221144,0.0003229216,0.2927774,0.6743425,0.01112368,0.0007440122,0.01192875],"study_design_scores_gemma":[0.0001771634,0.0005288612,0.006821743,0.00001619595,0.00006837308,0.0002741595,0.0002350608,0.8504447,0.1354181,0.001609315,0.00434446,0.0000618001],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927514,0.000124385,0.005438975,0.00008313531,0.000008364775,0.00001239014,0.00006085408,0.0000471343,0.001473358],"genre_scores_gemma":[0.9950676,0.0001482297,0.003846157,0.00001893551,0.000001188032,0.00001122194,0.0001021086,0.00001374648,0.0007907306],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006183817,"threshold_uncertainty_score":0.0122956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009835931530228019,"score_gpt":0.2738570767834621,"score_spread":0.2640211452532341,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}