{"id":"W1973130152","doi":"10.1111/cbdd.12475","title":"The Unique Binding Mode of Laulimalide to Two Tubulin Protofilaments","year":2014,"lang":"en","type":"article","venue":"Chemical Biology & Drug Design","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Allard Foundation; Alberta Cancer Foundation","keywords":"Tubulin; Microtubule; Chemistry; Plasma protein binding; Biophysics; Binding site; Molecular dynamics; Computational biology; Biology; Cell biology; Biochemistry; Computational chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000421512,0.0001820808,0.0002088043,0.00002999316,0.00008167561,0.00001272527,0.0004558572,0.0001769479,0.00000565392],"category_scores_gemma":[0.0002520312,0.0001330985,0.00009400275,0.00008917458,0.0001780534,0.000001984019,0.0001996521,0.0001262563,0.00002372841],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000185298,"about_ca_system_score_gemma":0.00005101855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000175784,"about_ca_topic_score_gemma":0.000006657667,"domain_scores_codex":[0.9987027,0.0001993183,0.0002991728,0.0003818706,0.00006124099,0.0003556758],"domain_scores_gemma":[0.9991699,0.0001089633,0.0001017752,0.0004339633,0.00007870804,0.0001067204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000126375,0.00003758939,0.0005098669,0.000007782704,0.0000405516,2.404359e-7,0.00002997359,0.00004390936,0.9942877,0.0004697678,0.0021191,0.002327156],"study_design_scores_gemma":[0.0003655538,0.00012957,0.000009140753,0.00001463666,0.00001385996,0.000004264916,0.00001427081,0.0002674444,0.975595,0.0005146709,0.02291166,0.0001599324],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9578379,0.0001181611,0.04038904,0.0003698219,0.00009519007,0.0007009022,0.00002063985,0.00001743273,0.0004508768],"genre_scores_gemma":[0.9913896,0.00008112418,0.007233276,0.0005085156,0.0001482389,0.0001764993,0.0001049004,0.00002441219,0.0003334247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03355167,"threshold_uncertainty_score":0.54276,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009835931530228019,"score_gpt":0.2738570767834621,"score_spread":0.2640211452532341,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}