{"id":"W1973161736","doi":"10.1093/carcin/24.1.17","title":"Human DNA methyltransferase gene DNMT1 is regulated by the APC pathway","year":2003,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute; Johns Hopkins University; McGill University; Israel Cancer Research Fund","keywords":"DNMT1; DNA methylation; Carcinogenesis; Epigenetics; DNA methyltransferase; Biology; Methyltransferase; Epigenomics; Cancer research; Gene; Colorectal cancer; Regulation of gene expression; Gene expression; Methylation; Genetics; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003852987,0.0002334232,0.0001724512,0.00003703241,0.0002881567,0.00003769898,0.0002365794,0.0002227447,0.0001046735],"category_scores_gemma":[0.00004940461,0.000185963,0.0001728384,0.000174963,0.00009703242,0.000003906058,0.0000336143,0.00007784041,0.00001499752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001807402,"about_ca_system_score_gemma":0.0000634007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004207688,"about_ca_topic_score_gemma":0.00001392118,"domain_scores_codex":[0.9984952,0.0002370341,0.0002755005,0.0004678293,0.000199075,0.0003253913],"domain_scores_gemma":[0.9989635,0.00001490738,0.00006797235,0.0007021651,0.0001273289,0.0001241404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000008435013,0.00003834824,0.002026372,0.000006370441,0.0000682959,0.000001799287,0.0000621086,0.00002339583,0.9944873,0.0001633878,0.001586101,0.001528121],"study_design_scores_gemma":[0.0003771601,0.0001113032,0.002861931,0.000002556976,0.00005416373,0.000004350191,0.00003640534,0.000006817167,0.9284242,0.0002243325,0.06765953,0.0002372036],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849933,0.01107155,0.001764292,0.0002006941,0.000132642,0.000241367,0.00007934943,0.00001730158,0.001499523],"genre_scores_gemma":[0.9964461,0.0003507893,0.0002112678,0.0005981128,0.0001151178,0.00003807995,0.0001842858,0.00004900892,0.002007249],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06607343,"threshold_uncertainty_score":0.7583353,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01412458577580787,"score_gpt":0.2419248671133856,"score_spread":0.2278002813375777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}