{"id":"W1973161736","doi":"10.1093/carcin/24.1.17","title":"Human DNA methyltransferase gene DNMT1 is regulated by the APC pathway","year":2003,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute; Johns Hopkins University; McGill University; Israel Cancer Research Fund","keywords":"DNMT1; DNA methylation; Carcinogenesis; Epigenetics; DNA methyltransferase; Biology; Methyltransferase; Epigenomics; Cancer research; Gene; Colorectal cancer; Regulation of gene expression; Gene expression; Methylation; Genetics; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007401657,0.0001787027,0.0001310837,0.0002051248,0.0001359203,0.0002086782,0.00007960269,0.0001180829,0.001126688],"category_scores_gemma":[0.0001768493,0.0001187932,0.00008650683,0.00009526173,0.0001139249,0.00009684758,0.0001593524,0.0002150261,0.0004610764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003299381,"about_ca_system_score_gemma":0.0001862085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000957553,"about_ca_topic_score_gemma":0.001248694,"domain_scores_codex":[0.9999367,0.000009522166,0.000003551278,0.00002046961,0.00001860171,0.00001111481],"domain_scores_gemma":[0.9999281,0.000009319264,0.00002978799,0.000006095936,0.0000130554,0.00001355273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008681688,0.000004712166,0.0006741728,0.00002082266,0.000003028216,0.00003634035,0.000009090355,0.00006197602,0.9961146,0.0001255037,0.0000484638,0.002814425],"study_design_scores_gemma":[0.00001723281,0.0001295838,0.0217429,0.00000813129,0.0000145935,0.0005065791,0.00002025723,0.001387882,0.9701613,0.0001920675,0.005814473,0.000005069391],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872981,0.004575106,0.004736906,0.0001732086,0.00002631628,0.00002162335,0.0005775581,0.0001772627,0.002413823],"genre_scores_gemma":[0.9928809,0.001354732,0.002077605,0.00002318988,0.000006336575,0.00001226649,0.0004653008,0.00001805661,0.003161536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001126688,"threshold_uncertainty_score":0.0037691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01412458577580787,"score_gpt":0.2419248671133856,"score_spread":0.2278002813375777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}