{"id":"W1973194025","doi":"10.1016/j.expneurol.2007.04.009","title":"NF-κB activated by ER calcium release inhibits Aβ-mediated expression of CHOP protein: Enhancement by AD-linked mutant presenilin 1","year":2007,"lang":"en","type":"article","venue":"Experimental Neurology","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"Alzheimer Society; Manitoba Medical Service Foundation","keywords":"CHOP; Unfolded protein response; Presenilin; Endoplasmic reticulum; Calcium in biology; Programmed cell death; Cell biology; Calcium; Biology; Endocrinology; Intracellular; Internal medicine; Chemistry; Apoptosis; Medicine; Biochemistry; Alzheimer's disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001050922,0.0003077266,0.0002779399,0.00005098627,0.00007695573,0.00001006822,0.0002225774,0.0003069509,0.0001929805],"category_scores_gemma":[0.00009778167,0.0002826096,0.0001082132,0.00009659351,0.0002168309,0.000009935462,0.0002279384,0.0001945103,0.00001333864],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001796078,"about_ca_system_score_gemma":0.00005066879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003610377,"about_ca_topic_score_gemma":0.000002506115,"domain_scores_codex":[0.9979502,0.000138401,0.0004873668,0.0006588676,0.0002597508,0.0005053961],"domain_scores_gemma":[0.9989644,0.00002901638,0.0002367533,0.0004208769,0.00006033681,0.0002886458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002056712,0.0009225602,0.0002562403,0.0000187612,0.00002555589,0.00003014805,0.00005480934,0.000002929574,0.989786,0.000003140597,0.006697452,0.0001456696],"study_design_scores_gemma":[0.002266561,0.001364673,0.00007455949,0.00001586901,0.00000667714,0.00001009928,0.00006769796,0.00002769804,0.9859391,0.000002573979,0.009971823,0.0002526263],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995696,0.002437557,0.0003294986,0.0001536486,0.0001663528,0.0006872926,0.0001393386,0.00002695602,0.0003633512],"genre_scores_gemma":[0.9979436,0.00006635349,0.00007896731,0.0005666766,0.00006681847,0.0001303691,0.0006855692,0.00004406949,0.0004175225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003846879,"threshold_uncertainty_score":0.9999626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007127929823669475,"score_gpt":0.2612301236317458,"score_spread":0.2541021938080763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}