{"id":"W1973256609","doi":"10.1074/jbc.m801164200","title":"Caspase-3 Activation Triggers Extracellular Cathepsin L Release and Endorepellin Proteolysis","year":2008,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research; Bristol-Myers Squibb Canada; Bristol-Myers Squibb","keywords":"Proteolysis; Proteases; Cell biology; Cathepsin; Extracellular; Apoptosis; Extracellular matrix; Matrix metalloproteinase; Caspase; Cysteine protease; Biology; Biochemistry; Calpain; Cathepsin S; Chemistry; Programmed cell death; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002361499,0.0001487675,0.0002089241,0.00002130973,0.00008674591,0.000009894508,0.000131893,0.0002730547,0.00005870231],"category_scores_gemma":[0.0003159252,0.0001084047,0.0001520775,0.00006453614,0.0001200179,0.000007591719,0.00004655677,0.0002137791,0.000001890741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001859799,"about_ca_system_score_gemma":0.00007801422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003269955,"about_ca_topic_score_gemma":7.923997e-8,"domain_scores_codex":[0.999082,0.00004993693,0.0003437096,0.0002131438,0.0001392199,0.000171939],"domain_scores_gemma":[0.9992493,0.00001841772,0.0002980362,0.0001593933,0.0001149505,0.0001598607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002315052,0.00009866037,0.0003219074,0.00001361348,0.00003493456,0.00007328936,0.00001536007,0.0000062705,0.9981225,0.000004069876,0.0003413896,0.0007365572],"study_design_scores_gemma":[0.0005671812,0.0003387417,0.0001139432,0.00002110038,0.00001503907,0.000680544,0.000040039,0.00001514817,0.9943515,0.0001395803,0.003577125,0.000140048],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961128,0.001953968,0.001466335,0.0001169244,0.00003148206,0.00009880921,0.000005609837,0.000005984025,0.0002080526],"genre_scores_gemma":[0.9969161,0.0009873452,0.001189929,0.00007636743,0.0004505502,0.000006840467,0.00002151205,0.000009518983,0.0003418798],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003770933,"threshold_uncertainty_score":0.4420615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02078946680235157,"score_gpt":0.2249855857206449,"score_spread":0.2041961189182933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}