{"id":"W1973256609","doi":"10.1074/jbc.m801164200","title":"Caspase-3 Activation Triggers Extracellular Cathepsin L Release and Endorepellin Proteolysis","year":2008,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research; Bristol-Myers Squibb Canada; Bristol-Myers Squibb","keywords":"Proteolysis; Proteases; Cell biology; Cathepsin; Extracellular; Apoptosis; Extracellular matrix; Matrix metalloproteinase; Caspase; Cysteine protease; Biology; Biochemistry; Calpain; Cathepsin S; Chemistry; Programmed cell death; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002605655,0.0003744017,0.0003059836,0.0002157521,0.0001494315,0.0003841137,0.0001641445,0.0005611535,0.0009845481],"category_scores_gemma":[0.000320164,0.0001442442,0.0004812138,0.0001819163,0.0002721357,0.0003768864,0.0002369841,0.0008281975,0.0004022537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004997881,"about_ca_system_score_gemma":0.0002156558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002789137,"about_ca_topic_score_gemma":0.0003439124,"domain_scores_codex":[0.9997134,0.00004455679,0.00002781202,0.00005926822,0.00007733352,0.00007769522],"domain_scores_gemma":[0.9997726,0.00004709247,0.00007420698,0.00002643878,0.0000379575,0.00004168228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001197321,0.00002014628,0.0003278754,0.00003208701,0.000006337932,0.0001529948,0.00001596349,0.00002535625,0.9980429,0.00009754057,0.00003548234,0.001123651],"study_design_scores_gemma":[0.00003621116,0.0001803118,0.007785213,0.000006037888,0.00001179367,0.001551018,0.00003400301,0.0007366929,0.9878577,0.0001862794,0.00160887,0.000005940721],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862178,0.003755741,0.008100757,0.0002178704,0.00004509631,0.00005234811,0.0003245274,0.00008145072,0.001204381],"genre_scores_gemma":[0.9942514,0.0009304346,0.00333903,0.00009638414,0.00001463316,0.00002759962,0.000370646,0.000007823158,0.0009621645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009845481,"threshold_uncertainty_score":0.003626227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02078946680235157,"score_gpt":0.2249855857206449,"score_spread":0.2041961189182933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}