{"id":"W1973285175","doi":"10.1128/jb.182.6.1515-1522.2000","title":"Evolution of Drug Resistance in Experimental Populations of <i>Candida albicans</i>","year":2000,"lang":"en","type":"article","venue":"Journal of Bacteriology","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":207,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Pfizer Canada; Pfizer","keywords":"Biology; Fluconazole; Candida albicans; Drug resistance; Azole; Microbiology; Antifungal drug; Genetics; Itraconazole; Gene; Ketoconazole; Antifungal","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005789219,0.0004043153,0.0003609567,0.0002149646,0.0003852755,0.00041053,0.0008682287,0.0005648752,0.0008812908],"category_scores_gemma":[0.0009466819,0.0002252082,0.0004326567,0.000213203,0.000315951,0.0001847319,0.000557758,0.0009610077,0.0002140416],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000541914,"about_ca_system_score_gemma":0.0002173692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001440044,"about_ca_topic_score_gemma":0.001731246,"domain_scores_codex":[0.9992502,0.0001860603,0.00009070343,0.0002409289,0.000147342,0.00008476862],"domain_scores_gemma":[0.9988575,0.0003512688,0.0001976755,0.0002338726,0.0001877856,0.0001719031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004993812,0.0003988268,0.004712606,0.00005927927,0.00005394845,0.0001210708,0.0001083244,0.0006610656,0.990175,0.0001376629,0.0000976342,0.002975168],"study_design_scores_gemma":[0.0002798162,0.01062711,0.09305571,0.00003758362,0.0002170963,0.001282489,0.0003646788,0.01007291,0.8800528,0.0002201369,0.003678886,0.0001108846],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979388,0.0001106374,0.00101914,0.00003086326,0.00001678501,0.0001021881,0.000236618,0.00002158585,0.0005233501],"genre_scores_gemma":[0.9879313,0.0001825685,0.00819124,0.0001464217,0.00003111445,0.0003933496,0.001912329,0.0000418858,0.001169908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001440044,"threshold_uncertainty_score":0.00393188,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01513412703131902,"score_gpt":0.2917791401757531,"score_spread":0.2766450131444341,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}