{"id":"W1973288655","doi":"10.1016/s0166-3542(00)00085-1","title":"A novel high throughput screening assay for HCV NS3 helicase activity","year":2000,"lang":"en","type":"article","venue":"Antiviral Research","topic":"Hepatitis C virus research","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"BioPhage Pharma (Canada)","funders":"","keywords":"Helicase; Biotinylation; NS3; Oligonucleotide; Chemistry; DNA; Molecular biology; High-throughput screening; Recombinant DNA; Biochemistry; Escherichia coli; Biology; Enzyme; Protease; RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.004203178,0.0002336679,0.0004825999,0.0004179701,0.0005306441,0.0001435266,0.0003557061,0.0002388663,0.0008497303],"category_scores_gemma":[0.002225688,0.0002076344,0.0002075339,0.00112106,0.0004515664,0.0004022284,0.0002073133,0.001260262,0.001120791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001919264,"about_ca_system_score_gemma":0.0004863814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004235217,"about_ca_topic_score_gemma":0.0003226453,"domain_scores_codex":[0.9952879,0.0004256976,0.0002950291,0.0007684316,0.001676496,0.001546479],"domain_scores_gemma":[0.9968132,0.001436303,0.00003326309,0.0007948083,0.000639802,0.0002825868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003625768,0.0007192307,0.002940791,0.0001772528,0.0001190296,0.0002991004,0.0001415877,0.000001343823,0.1382089,0.000714305,0.01187797,0.8411747],"study_design_scores_gemma":[0.01670098,0.009527981,0.05840086,0.0009632361,0.0001025996,0.0001318558,0.0002215879,0.02873818,0.3859475,0.001383693,0.4966274,0.001254168],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9341486,0.00009865349,0.008318927,0.005894582,0.0000539023,0.002112336,0.0001840846,0.0001322075,0.04905679],"genre_scores_gemma":[0.9689643,0.0002983544,0.006985543,0.0002309623,0.0005262958,0.000259823,0.00005342349,0.00008373336,0.02259755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8399205,"threshold_uncertainty_score":0.999657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2296371027989056,"score_gpt":0.4795701508401942,"score_spread":0.2499330480412887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}