{"id":"W1973288655","doi":"10.1016/s0166-3542(00)00085-1","title":"A novel high throughput screening assay for HCV NS3 helicase activity","year":2000,"lang":"en","type":"article","venue":"Antiviral Research","topic":"Hepatitis C virus research","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"BioPhage Pharma (Canada)","funders":"","keywords":"Helicase; Biotinylation; NS3; Oligonucleotide; Chemistry; DNA; Molecular biology; High-throughput screening; Recombinant DNA; Biochemistry; Escherichia coli; Biology; Enzyme; Protease; RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008143608,0.00162816,0.001130408,0.001424079,0.0005983368,0.0007642862,0.000852732,0.0008331418,0.002339074],"category_scores_gemma":[0.0005205597,0.0005423385,0.0006909434,0.0008662134,0.000332898,0.0003977762,0.0008282413,0.001132198,0.002366767],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005584115,"about_ca_system_score_gemma":0.0005576517,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001227477,"about_ca_topic_score_gemma":0.003513211,"domain_scores_codex":[0.9986565,0.0003135361,0.0000731285,0.0001649918,0.0006530366,0.0001389055],"domain_scores_gemma":[0.9996293,0.0001478539,0.00003499627,0.0000444578,0.00008707278,0.0000562947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001111801,0.0002091622,0.0003389564,0.00006681587,0.00002639884,0.0000323583,0.00001501478,0.0001013338,0.9922883,0.00004981189,0.0005575,0.006203256],"study_design_scores_gemma":[0.00007272144,0.0007460003,0.003060809,0.00001074141,0.00006763371,0.0004090455,0.00002219923,0.003051348,0.9887977,0.00008235007,0.00364749,0.00003191815],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.6919268,0.006741241,0.2707954,0.001213677,0.0004909404,0.002521255,0.009761645,0.005098754,0.01145039],"genre_scores_gemma":[0.7537233,0.004199507,0.1842974,0.0007963101,0.000235094,0.00229295,0.02423377,0.0002563005,0.02996547],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.002339074,"threshold_uncertainty_score":0.007824957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2296371027989056,"score_gpt":0.4795701508401942,"score_spread":0.2499330480412887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}