{"id":"W1973300568","doi":"10.1101/gad.235184.113","title":"Cellular senescence and its effector programs","year":2014,"lang":"en","type":"review","venue":"Genes & Development","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":843,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; University of Cambridge; Cancer Research UK","keywords":"Senescence; Effector; Biology; Phenotype; Cell biology; Suppressor; Cellular senescence; Cell; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005304256,0.0008456567,0.00114229,0.002969776,0.000424029,0.001268687,0.0007147854,0.001092099,0.003132971],"category_scores_gemma":[0.0005038521,0.0002464247,0.0003389216,0.001982891,0.0007667226,0.001464941,0.0009118123,0.001565222,0.002710496],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009173139,"about_ca_system_score_gemma":0.0009118901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007862134,"about_ca_topic_score_gemma":0.000935642,"domain_scores_codex":[0.9997888,0.00003304936,0.00003178551,0.00004744262,0.00007870619,0.00002019955],"domain_scores_gemma":[0.9997832,0.00007303611,0.00003228547,0.00001025371,0.00006996297,0.00003128094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006061032,0.00005537727,0.0002701421,0.009084442,0.00004313433,0.0002452123,0.0001241854,0.000330017,0.004591073,0.01310836,0.02210221,0.9499853],"study_design_scores_gemma":[0.000004859497,0.00004583224,0.00065889,0.001231678,0.00002841092,0.001055035,0.00004670492,0.00004493372,0.0009333162,0.002864702,0.9930715,0.00001404257],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001413403,0.9973538,0.0002164368,0.0002113474,0.0001811394,0.000004860451,0.00001948247,0.00001094927,0.001860618],"genre_scores_gemma":[0.00129074,0.9968081,0.0002091585,0.0001590064,0.0002238111,0.00001108239,0.00003964181,0.000002364845,0.001256108],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003132971,"threshold_uncertainty_score":0.01048082,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04598794355104572,"score_gpt":0.3056469269903437,"score_spread":0.2596589834392979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}