{"id":"W1973308215","doi":"10.1371/journal.pone.0062345","title":"Selective Activation of KCa3.1 and CRAC Channels by P2Y2 Receptors Promotes Ca2+ Signaling, Store Refilling and Migration of Rat Microglial Cells","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"ORAI1; Ionotropic effect; Metabotropic receptor; Cell biology; P2Y receptor; Purinergic receptor; Receptor; Microglia; Ligand-gated ion channel; Calcium signaling; Chemistry; Intracellular; Neuroscience; Biology; Ion channel; Glutamate receptor; Biochemistry; STIM1; Extracellular; Immunology; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001165483,0.0001349554,0.0002396278,0.00009539806,0.0001025846,0.00003032203,0.00006525382,0.0001064463,0.000060261],"category_scores_gemma":[0.000181838,0.0001169049,0.00002509078,0.0001786971,0.0001271663,0.0002863712,0.00003704772,0.0001210694,0.000003069896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002274788,"about_ca_system_score_gemma":0.00001915049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002206074,"about_ca_topic_score_gemma":0.000004342618,"domain_scores_codex":[0.998941,0.0001008096,0.0002555167,0.0002964282,0.0002427935,0.0001634712],"domain_scores_gemma":[0.9992781,0.0001631346,0.0002603621,0.00006793537,0.0001697934,0.00006069972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002790196,0.0002993972,0.0002387628,0.000130358,0.00001720095,7.56939e-8,0.002259464,0.000009385656,0.9962881,0.000006798277,0.0003835428,0.0003390496],"study_design_scores_gemma":[0.0002503337,0.0003005559,0.00002474636,0.0001466074,0.00002315527,4.418868e-7,0.0001533265,0.001412392,0.997406,0.0001324509,0.00002732753,0.0001226578],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998917,0.00005866357,0.00005814588,0.0002248528,0.0001450783,0.0005316301,0.00001519087,0.00002258212,0.00002679641],"genre_scores_gemma":[0.9986267,0.000188408,0.0005084525,0.00003797524,0.00009499889,0.00002596574,0.000008603438,0.00001831307,0.0004905934],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002106138,"threshold_uncertainty_score":0.4767243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02960541697877098,"score_gpt":0.2141426961570232,"score_spread":0.1845372791782522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}