{"id":"W1973308215","doi":"10.1371/journal.pone.0062345","title":"Selective Activation of KCa3.1 and CRAC Channels by P2Y2 Receptors Promotes Ca2+ Signaling, Store Refilling and Migration of Rat Microglial Cells","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"ORAI1; Ionotropic effect; Metabotropic receptor; Cell biology; P2Y receptor; Purinergic receptor; Receptor; Microglia; Ligand-gated ion channel; Calcium signaling; Chemistry; Intracellular; Neuroscience; Biology; Ion channel; Glutamate receptor; Biochemistry; STIM1; Extracellular; Immunology; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000391613,0.0005737268,0.000675146,0.0002898106,0.0002785152,0.0003543815,0.0003862547,0.0004664764,0.00103445],"category_scores_gemma":[0.0002451279,0.0002371292,0.0008105371,0.0003357021,0.0003564206,0.0005119621,0.0002926619,0.0008499795,0.0005028469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000532345,"about_ca_system_score_gemma":0.0005693289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001892171,"about_ca_topic_score_gemma":0.003393657,"domain_scores_codex":[0.9994051,0.00005145909,0.00006590536,0.00008257796,0.00008185598,0.0003131084],"domain_scores_gemma":[0.9998333,0.0000252004,0.00003949368,0.00002474303,0.00002295797,0.00005425774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005169404,0.00003517888,0.00007805371,0.00005426536,0.000004904788,0.00007442739,0.00002323998,0.00003344726,0.9984708,0.00006708249,0.00005297328,0.0005886858],"study_design_scores_gemma":[0.00008877499,0.0007397659,0.004048844,0.0000101642,0.00002538346,0.0002598108,0.00005371156,0.0006637612,0.9930352,0.00004323759,0.001023908,0.000007431423],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933809,0.002782905,0.001869423,0.0001764126,0.00005441398,0.00005636992,0.0005523908,0.0001067998,0.001020398],"genre_scores_gemma":[0.9922616,0.001731679,0.003470406,0.0001059705,0.00004149067,0.0001617122,0.000497468,0.00002933931,0.001700151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001892171,"threshold_uncertainty_score":0.003862441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02960541697877098,"score_gpt":0.2141426961570232,"score_spread":0.1845372791782522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}