{"id":"W1973344697","doi":"10.1016/j.drup.2015.01.001","title":"RhoGTPases – A novel link between cytoskeleton organization and cisplatin resistance","year":2015,"lang":"en","type":"review","venue":"Drug Resistance Updates","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"RhoC; RHOA; RHOB; Biology; Actin cytoskeleton; Cell biology; PAK1; CDC42; Cisplatin; GTPase; Cytoskeleton; Cancer research; Kinase; Signal transduction; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000411173,0.0005860282,0.0009940459,0.001022331,0.0001889738,0.0009129268,0.0006235386,0.001051206,0.002092767],"category_scores_gemma":[0.0005261412,0.0002097039,0.0003019042,0.0009844674,0.0004330815,0.001137168,0.0006409599,0.00179657,0.001232213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004738751,"about_ca_system_score_gemma":0.0008055112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005417115,"about_ca_topic_score_gemma":0.001466402,"domain_scores_codex":[0.9998864,0.00001404428,0.00001850584,0.00002270699,0.00004480908,0.00001355963],"domain_scores_gemma":[0.999848,0.00005872418,0.00002676641,0.000005514887,0.00004234365,0.00001865034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001277106,0.00004803367,0.0002640059,0.007920248,0.00008029657,0.0003181314,0.00004423825,0.0003197413,0.004262044,0.005725458,0.04613652,0.9347536],"study_design_scores_gemma":[0.00002429846,0.00006700726,0.0009873864,0.001294614,0.0001293523,0.001330328,0.00004334648,0.0001620329,0.0009043239,0.002657056,0.9923805,0.00001988516],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001911177,0.9979805,0.0002073551,0.000667714,0.0003184896,0.000003048861,0.00002113741,0.00001015186,0.0006004671],"genre_scores_gemma":[0.001177729,0.9970542,0.0002309451,0.0003334606,0.0004454375,0.000004351005,0.00004518049,0.000001614792,0.0007070485],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002092767,"threshold_uncertainty_score":0.007001042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02294902211328728,"score_gpt":0.2889868471376309,"score_spread":0.2660378250243436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}