{"id":"W1973354423","doi":"10.1056/nejmoa1314258","title":"Secukinumab in Plaque Psoriasis — Results of Two Phase 3 Trials","year":2014,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":1964,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research; Dalhousie University","funders":"","keywords":"Secukinumab; Medicine; Psoriasis; Psoriasis Area and Severity Index; Etanercept; Placebo; Dosing; Dermatology Life Quality Index; Clinical endpoint; Internal medicine; Dermatology; Clinical trial; Psoriatic arthritis; Tumor necrosis factor alpha; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01401928,0.001738233,0.003541421,0.0005076581,0.0005636122,0.00184558,0.001085333,0.002543557,0.0037634],"category_scores_gemma":[0.008172397,0.0006662466,0.004479413,0.000825549,0.0009689005,0.001117863,0.0005951449,0.003224139,0.0007132459],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00114506,"about_ca_system_score_gemma":0.001560582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009222029,"about_ca_topic_score_gemma":0.001709734,"domain_scores_codex":[0.9952135,0.003069593,0.000431455,0.0003727635,0.0005751106,0.0003374576],"domain_scores_gemma":[0.9933215,0.0027637,0.001598988,0.0006340899,0.0007258618,0.0009559162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8206075,0.009315564,0.004133096,0.005905224,0.0121571,0.0001879833,0.0002919179,0.001115428,0.00859778,0.0003368686,0.006768653,0.1305828],"study_design_scores_gemma":[0.8980144,0.07721806,0.01161625,0.0006079682,0.005092713,0.0001959329,0.00004837009,0.0004921758,0.001106325,0.0003841283,0.005178971,0.00004481115],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8035862,0.1619918,0.003253622,0.004790064,0.001608164,0.01025053,0.005255206,0.0004317332,0.00883266],"genre_scores_gemma":[0.922587,0.04946359,0.004373063,0.006213618,0.00159659,0.008498231,0.004524642,0.0001282111,0.002615035],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01401928,"threshold_uncertainty_score":0.07414192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0397480406814782,"score_gpt":0.3245614633366991,"score_spread":0.2848134226552209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}