{"id":"W1973364640","doi":"10.1016/j.nicl.2013.04.014","title":"Arterial spin labeled MRI in prodromal Alzheimer's disease: A multi-site study","year":2013,"lang":"en","type":"article","venue":"NeuroImage Clinical","topic":"Advanced MRI Techniques and Applications","field":"Medicine","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Deafness and Other Communication Disorders; National Institute of Mental Health; University of California, San Diego; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; University of California, Los Angeles; Genentech; National Institutes of Health; Servier; Eisai; Northern California Institute for Research and Education; Bayer HealthCare; GE Healthcare; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; National Institute of Neurological Disorders and Stroke; IXICO; Takeda Pharmaceutical Company; Medpace; National Center for Research Resources; F. Hoffmann-La Roche; BioClinica; Pfizer; Biogen; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; Novartis Pharmaceuticals Corporation; Alzheimer's Association; Amorfix Life Sciences; Alzheimer's Drug Discovery Foundation; Merck; National Institute on Aging; Abbott Laboratories; Synarc; Roche; Foundation for the National Institutes of Health","keywords":"Cerebral blood flow; Cardiology; Biomarker; Dementia; Medicine; Neuroimaging; Alzheimer's disease; Internal medicine; Magnetic resonance imaging; Arterial spin labeling; Context (archaeology); Clinical Dementia Rating; Population; Disease; Imaging biomarker; Hippocampal formation; Pathology; Psychology; Neuroscience; Radiology; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002203765,0.0006716519,0.0006135575,0.001060961,0.000581566,0.0006561586,0.0006219115,0.0006754497,0.0008846059],"category_scores_gemma":[0.002242659,0.000483868,0.0005477376,0.0007213579,0.000475995,0.000697197,0.0006700995,0.0004762945,0.000324554],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003336755,"about_ca_system_score_gemma":0.0003298686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004147945,"about_ca_topic_score_gemma":0.007814048,"domain_scores_codex":[0.9992793,0.0002874368,0.00004884917,0.0001938493,0.0001168273,0.00007370211],"domain_scores_gemma":[0.9978172,0.0003070481,0.0007190811,0.0004763761,0.0003194199,0.0003609963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002140332,0.0004374418,0.9864362,0.00005137518,0.0004043599,0.0009998892,0.0007242558,0.000118006,0.004292742,0.00004286086,0.00007863713,0.004273849],"study_design_scores_gemma":[0.00006325409,0.001080609,0.9966463,0.00000835857,0.0001593654,0.001091335,0.000216777,0.0002164182,0.0002405811,0.00006444326,0.000202176,0.00001023732],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999543,0.0001779376,0.00007929333,0.000009970355,0.000002181416,0.00001078251,0.0000492762,0.000001830721,0.0001258853],"genre_scores_gemma":[0.9995115,0.00008367244,0.0001715348,0.00001312945,0.000009494057,0.00000818531,0.00008590202,0.000002631037,0.0001138818],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004147945,"threshold_uncertainty_score":0.01165473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09824424724525664,"score_gpt":0.4461889704089155,"score_spread":0.3479447231636588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}