{"id":"W1973372400","doi":"10.1016/j.bbrc.2005.09.166","title":"Stereo-specificity for pro-(R) hydrogen of NAD(P)H during enzyme-catalyzed hydride transfer to CL-20","year":2005,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Chemical Reactions and Isotopes","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"Biotechnology Research Institute","funders":"","keywords":"Chemistry; Hydride; NAD+ kinase; Diaphorase; Deuterium; Enzyme; Kinetic isotope effect; Dehydrogenase; Cofactor; Stereochemistry; Biotransformation; Medicinal chemistry; Hydrogen; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005464111,0.0002203367,0.0001633768,0.0001014168,0.0002538154,0.0003050414,0.0005080875,0.0002943703,0.001806826],"category_scores_gemma":[0.0004795671,0.0001831639,0.0001433764,0.00008905545,0.0004721593,0.0003301219,0.0002512615,0.0004732449,0.0004172854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005296918,"about_ca_system_score_gemma":0.0004796807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001118269,"about_ca_topic_score_gemma":0.001729094,"domain_scores_codex":[0.9997879,0.0000445223,0.00001090099,0.00005225951,0.00003251979,0.00007198653],"domain_scores_gemma":[0.9997045,0.0001015457,0.00003835371,0.00005970321,0.00004617464,0.00004971488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000443042,0.00002066568,0.0002897121,0.00002795021,0.000004205797,0.00008628505,0.0000725647,0.00009750588,0.9956614,0.000881734,0.00009673822,0.002318202],"study_design_scores_gemma":[0.00001107278,0.00005852105,0.0003704303,0.000001168447,0.000001822596,0.00005690861,0.00001734819,0.0002466562,0.9985756,0.00005165464,0.0006057241,0.000003210635],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833131,0.000239564,0.009703975,0.0001651404,0.00004919714,0.00004741035,0.0001286281,0.0001582469,0.006194611],"genre_scores_gemma":[0.9971544,0.0000742533,0.001275253,0.00003673801,0.000004312591,0.00001106928,0.00009905366,0.00002785134,0.001317168],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001806826,"threshold_uncertainty_score":0.006044447,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2580591534808176,"score_gpt":0.488476112978005,"score_spread":0.2304169594971873,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}