{"id":"W1973377028","doi":"10.1021/ja046964y","title":"Triggering DNAzymes with Light:  A Photoactive C8 Thioether-Linked Adenosine","year":2004,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Chemistry; Thioether; Deoxyribozyme; Adenosine; Photochemistry; Stereochemistry; Biochemistry; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001382227,0.0001550468,0.0002847267,0.00001246691,0.00007615601,0.00001760063,0.0002869727,0.00007267855,6.42015e-7],"category_scores_gemma":[0.0000545335,0.00008367244,0.0004714948,0.000251399,0.0003581893,0.000005986227,0.00008418364,0.0002885275,3.296533e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008364511,"about_ca_system_score_gemma":0.00009241761,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001219804,"about_ca_topic_score_gemma":0.00000182063,"domain_scores_codex":[0.9991465,0.0000279968,0.0002369803,0.0001700979,0.0002302996,0.0001881017],"domain_scores_gemma":[0.9989536,0.00001341419,0.0005758074,0.0002302698,0.000155026,0.00007181597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001771589,0.00007792213,0.000149967,0.000003393173,0.0002441399,0.000002372094,0.00008813873,0.00002572742,0.9977093,0.000002273442,0.0005753197,0.000944318],"study_design_scores_gemma":[0.0004660194,0.0003254143,0.0002315523,0.00004964549,0.00009359166,0.0001199431,0.0003627642,0.000004428614,0.9950849,0.0001116659,0.003012057,0.0001379885],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959353,0.0001736034,0.001335136,0.002391272,0.00002387906,0.0000597513,0.000003297069,0.00001218059,0.00006560532],"genre_scores_gemma":[0.9826742,0.0002376751,0.01581022,0.0009375454,0.0002705194,0.000001402286,0.000001988595,0.00001812025,0.00004826561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01447509,"threshold_uncertainty_score":0.3412063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006288498152502736,"score_gpt":0.2538306519704878,"score_spread":0.2475421538179851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}