{"id":"W1973397721","doi":"10.1080/03639040802526789","title":"Ultrafine chitosan nanoparticles as an efficient nucleic acid delivery system targeting neuronal cells","year":2009,"lang":"en","type":"article","venue":"Drug Development and Industrial Pharmacy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"Chitosan; Transfection; Biocompatibility; Gene delivery; Nanoparticle; Cationic polymerization; Chemistry; Nucleic acid; Biophysics; Surface charge; Drug carrier; Drug delivery; Linker; Nanotechnology; Materials science; Biochemistry; Polymer chemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001756285,0.0002951355,0.00012834,0.0002459633,0.000137722,0.0002994467,0.0002813455,0.0003773157,0.0006330298],"category_scores_gemma":[0.0001944672,0.0001039125,0.0001484804,0.0001395035,0.0002283932,0.0002204045,0.0001713071,0.0002359196,0.0002068423],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008864926,"about_ca_system_score_gemma":0.000307325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001793136,"about_ca_topic_score_gemma":0.002565759,"domain_scores_codex":[0.999915,0.000009439853,0.000005697438,0.00001974334,0.00003534883,0.00001465877],"domain_scores_gemma":[0.9999038,0.00001936595,0.00002440718,0.00000650861,0.00003045372,0.00001547903],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003461562,0.00001603706,0.00006845262,0.00004865415,0.00000395905,0.00002860112,0.000006797828,0.0001687932,0.9965777,0.0001212537,0.00008108565,0.002844172],"study_design_scores_gemma":[0.00001842668,0.0001381747,0.0005364983,0.000004416222,0.00001547173,0.00009062851,0.000003393405,0.001534178,0.9953122,0.00002700539,0.002314388,0.000005254024],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.966714,0.004568058,0.02334195,0.0003325955,0.000098404,0.0001104947,0.0002007407,0.0002986299,0.004335127],"genre_scores_gemma":[0.9781608,0.001153193,0.01603989,0.0000988821,0.00002526443,0.00005287828,0.0002034051,0.00003726239,0.004228369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001793136,"threshold_uncertainty_score":0.006432056,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02064011195436925,"score_gpt":0.2494827229736393,"score_spread":0.2288426110192701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}