{"id":"W1973399879","doi":"10.1139/o04-124","title":"Influence of mechanical and biological signals on gene expression in human MG-63 cells: evidence for a complex interplay between hydrostatic compression and vitamin D3 or TGF-β1 on MMP-1 and MMP-3 mRNA levels","year":2005,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Bone Tissue Engineering Materials","field":"Engineering","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Bone and Joint Health Institute","funders":"Canadian Space Agency; Killam Trusts; Calgary Foundation","keywords":"Osteocalcin; Gene expression; Messenger RNA; Transforming growth factor; Internal medicine; Endocrinology; Matrix metalloproteinase; Hydrostatic pressure; Chemistry; Biology; Molecular biology; Cell biology; Alkaline phosphatase; Gene; Enzyme; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002161503,0.0002299584,0.0004086553,0.00004896557,0.0000435437,0.00001566212,0.00009868872,0.0002715026,0.00001759003],"category_scores_gemma":[0.00006686462,0.0001797701,0.00001721389,0.00003844959,0.0001378784,0.00003991548,0.00009830127,0.0001285085,6.366692e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001932297,"about_ca_system_score_gemma":0.000005379315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004411262,"about_ca_topic_score_gemma":6.501405e-7,"domain_scores_codex":[0.9989579,0.00005327082,0.0003552441,0.0003614361,0.00004678539,0.0002253553],"domain_scores_gemma":[0.9991251,0.0005498582,0.00007113173,0.0001431717,0.00001322735,0.00009753452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001261788,0.00002606855,0.0002495405,0.0003753456,0.000008005117,0.000001868768,0.0000844079,0.000815061,0.9974647,0.000005151046,0.00002798687,0.0008157301],"study_design_scores_gemma":[0.0007065696,0.000461047,0.00273927,0.0004761339,0.00001029601,0.000005474881,0.00001863122,0.001785527,0.9934162,0.00005508531,0.0001158509,0.0002099459],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984998,0.0006685699,0.0003939692,0.00002629148,0.00002123747,0.0002291237,0.0001132561,0.00003725059,0.00001054426],"genre_scores_gemma":[0.9977551,0.0002571616,0.001821903,0.00002478201,0.00005767435,0.0000272595,0.00002559711,0.00001510506,0.00001539188],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004048487,"threshold_uncertainty_score":0.7330813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05089177502445456,"score_gpt":0.3072073172404839,"score_spread":0.2563155422160294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}