{"id":"W1973415773","doi":"10.1002/cncr.23607","title":"No significance of derivative chromosome 9 deletion on the clearance kinetics of <i>BCR</i>/<i>ABL</i> fusion transcripts, cytogenetic or molecular response, loss of response, or treatment failure to imatinib mesylate therapy for chronic myeloid leukemia","year":2008,"lang":"en","type":"article","venue":"Cancer","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Imatinib mesylate; breakpoint cluster region; ABL; Imatinib; Medicine; Fluorescence in situ hybridization; Philadelphia chromosome; Myeloid leukemia; Fusion gene; Fusion transcript; Molecular biology; Cancer research; Internal medicine; Tyrosine kinase; Biology; Chromosomal translocation; Chromosome; Gene; Genetics; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003094257,0.0004707715,0.0009421034,0.0001597339,0.00009680313,0.000005155841,0.0002865964,0.000191437,0.000330773],"category_scores_gemma":[0.0003044595,0.0002871909,0.0002859919,0.0006818596,0.0004090118,0.00004851637,0.0000258837,0.0001563373,0.000009049109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002976828,"about_ca_system_score_gemma":0.003017346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000166531,"about_ca_topic_score_gemma":0.00009928078,"domain_scores_codex":[0.9971784,0.0003548696,0.0008337401,0.000577952,0.0005828254,0.0004722655],"domain_scores_gemma":[0.9971047,0.0008133223,0.0004958183,0.0008932566,0.0005426082,0.0001503072],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.1401701,0.0003597261,0.0001602698,0.0002721749,0.0003537436,0.00005425354,0.001776533,0.001826372,0.8506221,0.00001552375,0.00056306,0.003826222],"study_design_scores_gemma":[0.01210657,0.01883982,0.01006582,0.001004563,0.0001729445,0.00003927488,0.00008893717,0.0002186493,0.9383494,0.000009588497,0.0188459,0.0002584929],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906346,0.00255658,0.0006471133,0.001376162,0.0001194093,0.004125505,0.0004656301,0.00003159837,0.00004344754],"genre_scores_gemma":[0.9897055,0.004647779,0.002058788,0.0005249495,0.0001016886,0.001147095,0.00002777499,0.0001007441,0.00168568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1280635,"threshold_uncertainty_score":0.999958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03888736965436139,"score_gpt":0.301315502515052,"score_spread":0.2624281328606906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}