{"id":"W1973415773","doi":"10.1002/cncr.23607","title":"No significance of derivative chromosome 9 deletion on the clearance kinetics of <i>BCR</i>/<i>ABL</i> fusion transcripts, cytogenetic or molecular response, loss of response, or treatment failure to imatinib mesylate therapy for chronic myeloid leukemia","year":2008,"lang":"en","type":"article","venue":"Cancer","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Imatinib mesylate; breakpoint cluster region; ABL; Imatinib; Medicine; Fluorescence in situ hybridization; Philadelphia chromosome; Myeloid leukemia; Fusion gene; Fusion transcript; Molecular biology; Cancer research; Internal medicine; Tyrosine kinase; Biology; Chromosomal translocation; Chromosome; Gene; Genetics; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005650562,0.00009140043,0.0001729918,0.0001532333,0.00009521168,0.0002095066,0.00009925158,0.0002120944,0.002044691],"category_scores_gemma":[0.001711505,0.00006471694,0.0001149236,0.00008244628,0.0002795226,0.0001751579,0.0001294164,0.0002356821,0.0002289489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002269103,"about_ca_system_score_gemma":0.0001188684,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001955939,"about_ca_topic_score_gemma":0.0002979119,"domain_scores_codex":[0.9997205,0.00009135586,0.00002239972,0.00006834967,0.00005468442,0.00004271213],"domain_scores_gemma":[0.9978116,0.001396867,0.0003923658,0.0001146644,0.0001090026,0.0001755491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006282358,0.0001204203,0.855349,0.00009016226,0.0000730977,0.001421261,0.0002725564,0.0003931855,0.1056073,0.0001354902,0.0001453369,0.03010987],"study_design_scores_gemma":[0.00008759803,0.005186407,0.9510837,0.000008552613,0.00009175872,0.008745268,0.0001326745,0.0008351313,0.03215332,0.00007938329,0.001585594,0.00001062208],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989166,0.0002676193,0.0001688298,0.00001670277,0.000002138962,0.000004265205,0.00002645956,0.000004986634,0.0005923797],"genre_scores_gemma":[0.9997898,0.00002520577,0.00006879708,0.00000931578,0.000002078962,0.000002887994,0.00003402768,0.000001360347,0.00006663363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002044691,"threshold_uncertainty_score":0.00684011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03888736965436139,"score_gpt":0.301315502515052,"score_spread":0.2624281328606906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}