{"id":"W1973418386","doi":"10.1038/jcbfm.2011.184","title":"Dynamic, Adaptive Changes in MAO-A Binding after Alterations in Substrate Availability: An <i>in vivo</i> [ <sup>11</sup> C]-Harmine Positron Emission Tomography Study","year":2011,"lang":"en","type":"article","venue":"Journal of Cerebral Blood Flow & Metabolism","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; GlaxoSmithKline (Canada); University of Toronto; SickKids Foundation; Centre for Addiction and Mental Health","funders":"National Institute on Drug Abuse; Canadian Institutes of Health Research","keywords":"Harmine; Monoamine neurotransmitter; Positron emission tomography; Monoamine oxidase; Monoamine oxidase A; Monoamine oxidase B; Internal medicine; Neurotransmitter; Striatum; Endocrinology; Chemistry; Serotonin; Neuroscience; Pharmacology; Psychology; Medicine; Dopamine; Biochemistry; Central nervous system; Receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002417665,0.0002407225,0.000307373,0.0001254853,0.0001751674,0.0003060306,0.0002112745,0.0003442173,0.001032955],"category_scores_gemma":[0.0002769621,0.0002233697,0.0001809799,0.0001337798,0.0004810466,0.000194611,0.0001295338,0.0006717107,0.0002142921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002438668,"about_ca_system_score_gemma":0.0001318081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001992383,"about_ca_topic_score_gemma":0.001642358,"domain_scores_codex":[0.9999371,0.00001913267,0.000002621248,0.00001735914,0.000007831005,0.00001594365],"domain_scores_gemma":[0.9998837,0.00002963991,0.00002171211,0.00002183019,0.00001245072,0.00003083359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0205093,0.001288305,0.02696147,0.00009265389,0.0001956508,0.001325562,0.0002914737,0.0002835825,0.936677,0.0002079504,0.0002312587,0.01193574],"study_design_scores_gemma":[0.001253896,0.02939369,0.7018656,0.00001276567,0.0005526497,0.007018676,0.0005627272,0.003434753,0.2515742,0.0005086352,0.003767457,0.00005497936],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990373,0.0003179412,0.0003297267,0.00002943189,0.00000417386,0.00001157554,0.00005453272,0.000004891991,0.0002104363],"genre_scores_gemma":[0.9987569,0.0002763308,0.0002813076,0.00004092191,0.00001234839,0.00001662928,0.0001195011,0.000005249771,0.0004908358],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001992383,"threshold_uncertainty_score":0.003961623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02863007867534541,"score_gpt":0.2653300187530825,"score_spread":0.2366999400777371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}