{"id":"W1973418386","doi":"10.1038/jcbfm.2011.184","title":"Dynamic, Adaptive Changes in MAO-A Binding after Alterations in Substrate Availability: An <i>in vivo</i> [ <sup>11</sup> C]-Harmine Positron Emission Tomography Study","year":2011,"lang":"en","type":"article","venue":"Journal of Cerebral Blood Flow & Metabolism","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; GlaxoSmithKline (Canada); University of Toronto; SickKids Foundation; Centre for Addiction and Mental Health","funders":"National Institute on Drug Abuse; Canadian Institutes of Health Research","keywords":"Harmine; Monoamine neurotransmitter; Positron emission tomography; Monoamine oxidase; Monoamine oxidase A; Monoamine oxidase B; Internal medicine; Neurotransmitter; Striatum; Endocrinology; Chemistry; Serotonin; Neuroscience; Pharmacology; Psychology; Medicine; Dopamine; Biochemistry; Central nervous system; Receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001053919,0.0004955232,0.0008527527,0.001730109,0.0000900304,0.0001348164,0.0007301521,0.0001549479,0.0004820973],"category_scores_gemma":[0.00008424152,0.0004385472,0.0002166994,0.00151102,0.000135515,0.001868631,0.00008555553,0.001049889,0.00001036894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007796197,"about_ca_system_score_gemma":0.00009955648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000181455,"about_ca_topic_score_gemma":0.001803776,"domain_scores_codex":[0.9952193,0.001092475,0.001368814,0.0007727345,0.0007923598,0.0007542718],"domain_scores_gemma":[0.9985288,0.00009444291,0.0004518657,0.0004670189,0.0001189765,0.0003389197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008073828,0.004343161,0.3548298,0.00001880134,0.00001567894,0.001041646,0.01145609,0.0001601113,0.6264011,0.00001338497,0.000004872357,0.0009079949],"study_design_scores_gemma":[0.006306735,0.00137392,0.4066304,0.0002490203,0.0002489915,0.0002406192,0.001267608,0.001157839,0.5816572,0.0001572864,0.00005339965,0.0006570058],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998117,0.0001725395,0.000009959618,0.0001651584,0.0003729106,0.001016562,0.00007342624,0.00002993227,0.00004254279],"genre_scores_gemma":[0.9978346,0.00006372902,0.001508822,0.0002942126,0.00009574193,0.00009477141,0.000001305396,0.00006143098,0.00004535043],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05180058,"threshold_uncertainty_score":0.9998066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02863007867534541,"score_gpt":0.2653300187530825,"score_spread":0.2366999400777371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}