{"id":"W1973471084","doi":"10.1002/jps.10249","title":"Effect of Cyclosporine A on the Binding Affinity and Internalization of Low-Density Lipoproteins in Human Skin Fibroblasts","year":2002,"lang":"en","type":"article","venue":"Journal of Pharmaceutical Sciences","topic":"Oral and gingival health research","field":"Health Professions","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Internalization; LDL receptor; Low-density lipoprotein; Chemistry; Receptor; Lipoprotein; Cholesterol; Endocrinology; Pharmacology; Binding site; Internal medicine; Biochemistry; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00561384,0.00007382051,0.0002549093,0.0001950147,0.0002968305,0.000007224167,0.0002258809,0.00005261453,0.0004002622],"category_scores_gemma":[0.0005059299,0.00003797401,0.00004850942,0.0004891944,0.0003285049,0.0001238286,0.00009941618,0.0006537344,0.000005318082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000561882,"about_ca_system_score_gemma":0.00004388123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001336746,"about_ca_topic_score_gemma":0.00004067066,"domain_scores_codex":[0.9975113,0.0009653743,0.0005767419,0.0001004736,0.0005685766,0.0002775843],"domain_scores_gemma":[0.9977857,0.001552249,0.0003733076,0.00005809174,0.00009234342,0.0001383491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001386612,0.0007808686,0.8235574,0.004066968,0.0000377766,0.00004582481,0.00408831,0.0001351664,0.1101738,0.007299599,0.000615219,0.04781248],"study_design_scores_gemma":[0.006902762,0.01490988,0.2806573,0.01204592,0.00006387827,0.00003842379,0.001387576,0.01933462,0.660073,0.003155149,0.001062733,0.0003687303],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997226,0.0001206141,0.00001956417,0.001612136,0.0001310844,0.0002898543,0.000001857828,0.000002499411,0.0005963928],"genre_scores_gemma":[0.9995742,0.0001531282,0.00002616326,0.00009049397,0.0001012604,0.000002273834,6.751739e-8,0.00000288332,0.00004946266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5498992,"threshold_uncertainty_score":0.4382591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1634323003998786,"score_gpt":0.5258672164557384,"score_spread":0.3624349160558598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}