{"id":"W1973492721","doi":"10.1021/jm030333h","title":"Syntheses, Calcium Channel Agonist−Antagonist Modulation Activities, and Nitric Oxide Release Studies of Nitrooxyalkyl 1,4-Dihydro-2,6-dimethyl-3-nitro-4-(2,1,3-benzoxadiazol-4-yl)pyridine-5-carboxylate Racemates, Enantiomers, and Diastereomers","year":2003,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":172,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Consejo Nacional de Ciencia y Tecnología","keywords":"Chemistry; Stereochemistry; Agonist; Dihydropyridine; Nitric oxide; Calcium; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001422798,0.0004746569,0.001438785,0.0003128893,0.0001659251,0.00003029078,0.0001329303,0.0002277767,0.00003416656],"category_scores_gemma":[0.002643507,0.0003748127,0.0002172071,0.0004503598,0.0005382406,0.0002512648,0.00006137613,0.0007759581,0.00000101334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002060208,"about_ca_system_score_gemma":0.00033047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006948358,"about_ca_topic_score_gemma":0.000001202147,"domain_scores_codex":[0.9969801,0.0001625356,0.001118636,0.0003771943,0.0008451269,0.0005163837],"domain_scores_gemma":[0.9965478,0.00108384,0.001098147,0.0003174093,0.000365331,0.0005875233],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001417267,0.0002849036,0.005953479,0.003295211,0.001101765,0.0007062315,0.0005014854,0.0000485196,0.9818515,0.0000166716,0.0005240481,0.004298945],"study_design_scores_gemma":[0.008467364,0.0008937286,0.007260423,0.003848146,0.002563458,0.008445163,0.008556818,0.000864245,0.9564579,0.0005346214,0.001379485,0.0007286146],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9738709,0.02437044,0.0001308361,0.000368062,0.0001998724,0.0002584427,0.00002728514,0.0000231609,0.0007510166],"genre_scores_gemma":[0.992326,0.006243803,0.0004725096,0.0001304631,0.0003998355,0.000009285351,0.000009200776,0.00005847862,0.0003503846],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02539354,"threshold_uncertainty_score":0.9998704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02937273770017543,"score_gpt":0.2906654031904063,"score_spread":0.2612926654902309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}