{"id":"W1973552252","doi":"10.1074/jbc.m212302200","title":"Agonist-independent Desensitization and Internalization of the Human Platelet-activating Factor Receptor by Coumermycin-Gyrase B-induced Dimerization","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Internalization; G protein-coupled receptor; Cell biology; Receptor; Agonist; Biology; Platelet-activating factor; Chemistry; Protein kinase C; Arrestin; Kinase; Biochemistry; Signal transduction; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001538254,0.0002287382,0.0002268975,0.0001052245,0.0001882106,0.000238977,0.0001579055,0.0002784549,0.0006717115],"category_scores_gemma":[0.0001128925,0.0001232347,0.0003471343,0.0001411668,0.0002054178,0.0001591038,0.0002484493,0.0005192949,0.0003272787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000499402,"about_ca_system_score_gemma":0.0001804322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001213388,"about_ca_topic_score_gemma":0.001671143,"domain_scores_codex":[0.9998153,0.00004893801,0.00001444131,0.00002787088,0.00004298323,0.00005047024],"domain_scores_gemma":[0.9999421,0.000010013,0.00001610755,0.0000116985,0.000005041258,0.00001516007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006249918,0.00001703249,0.00005883878,0.00001342387,0.000003423802,0.00003433882,0.00001213636,0.00002874182,0.9993793,0.00007966856,0.00002192633,0.0002885601],"study_design_scores_gemma":[0.00004026928,0.0002222144,0.006813986,0.000005902901,0.000009375975,0.0006153557,0.00003265656,0.002220039,0.9871196,0.00003642574,0.002876662,0.000007629318],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969517,0.001139838,0.0008500133,0.00008163355,0.00001041574,0.00002799294,0.0001691604,0.00002458913,0.000744599],"genre_scores_gemma":[0.9969642,0.0004866426,0.0009767654,0.00005111197,0.00000475355,0.00002633602,0.0003969082,0.000008071454,0.001085337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001213388,"threshold_uncertainty_score":0.003623426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01822667889730929,"score_gpt":0.2483125995676262,"score_spread":0.2300859206703169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}