{"id":"W1973555325","doi":"10.1016/j.nbd.2011.12.019","title":"P38 MAPK is involved in enhanced NMDA receptor-dependent excitotoxicity in YAC transgenic mouse model of Huntington disease","year":2011,"lang":"en","type":"article","venue":"Neurobiology of Disease","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":93,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Cure Huntington's Disease Initiative; CHDI Foundation","keywords":"Excitotoxicity; NMDA receptor; Huntingtin; Medium spiny neuron; p38 mitogen-activated protein kinases; Neurodegeneration; Protein kinase A; MAPK/ERK pathway; Cell biology; Biology; Striatum; Glutamate receptor; Chemistry; Kinase; Receptor; Molecular biology; Mutant; Neuroscience; Internal medicine; Biochemistry; Medicine; Dopamine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001472497,0.0004039479,0.0005612106,0.000393805,0.00004882476,0.00000734077,0.0007228565,0.0001105771,0.0002348384],"category_scores_gemma":[0.000594914,0.0004198531,0.0002542632,0.0004010977,0.0005614223,0.0001658278,0.0001768117,0.0002754608,0.00002141216],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003757378,"about_ca_system_score_gemma":0.0003026182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005666602,"about_ca_topic_score_gemma":0.00007773683,"domain_scores_codex":[0.9963912,0.0007108142,0.0008720029,0.001145854,0.0002924377,0.0005876302],"domain_scores_gemma":[0.9981727,0.0001578067,0.0003316927,0.0008031738,0.00008137916,0.0004532227],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001652307,0.001520942,0.03739108,0.0001513901,0.000005145257,4.28537e-7,0.000491629,0.002068946,0.9565278,0.0001131147,0.00003135964,0.00004590765],"study_design_scores_gemma":[0.001428336,0.0001752223,0.05398857,0.00004118876,0.00002147698,4.830934e-9,0.00003225015,0.0003051247,0.9429766,0.0007324045,0.000001515738,0.0002973197],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977503,0.00001419837,0.0001237276,0.00008265452,0.000179617,0.0008531245,0.0008417983,0.00004944036,0.0001050684],"genre_scores_gemma":[0.9985607,0.0001710926,0.0001021337,0.000819301,0.00001982563,0.0001296594,0.00001791479,0.00005146166,0.0001279485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01659749,"threshold_uncertainty_score":0.9998254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05314472029601383,"score_gpt":0.258135121695417,"score_spread":0.2049904013994031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}