{"id":"W1973585083","doi":"10.1038/onc.2010.366","title":"Suppression of Her2/neu expression through ILK inhibition is regulated by a pathway involving TWIST and YB-1","year":2010,"lang":"en","type":"article","venue":"Oncogene","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Drug Research and Development; BC Cancer Agency; Child and Family Research Institute; University of British Columbia","funders":"BC Cancer Agency; University of British Columbia; Canadian Breast Cancer Research Alliance","keywords":"Integrin-linked kinase; Gene silencing; Biology; Small interfering RNA; HER2/neu; Kinase; Molecular biology; Twist transcription factor; Cancer research; Cell culture; Cell biology; Protein kinase A; Transcription factor; Nuclear protein; Transfection; Biochemistry; Cancer; Breast cancer; Gene; Cyclin-dependent kinase 2; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001546633,0.0001194052,0.0001316182,0.00002453053,0.00009206439,0.00002233111,0.00008760964,0.0002037052,0.00006051925],"category_scores_gemma":[0.00007684052,0.0001016206,0.00004634998,0.00006665465,0.00009704429,0.00001199628,0.0001526664,0.0001339057,0.00000222476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000057051,"about_ca_system_score_gemma":0.00004117624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009958315,"about_ca_topic_score_gemma":0.00003382073,"domain_scores_codex":[0.9990893,0.00004723922,0.0001831441,0.0002989054,0.0001723852,0.0002090374],"domain_scores_gemma":[0.9994186,0.00001102397,0.00008618659,0.0002968204,0.00009325163,0.00009412248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008004251,0.00005299909,0.0005530891,0.00003053168,0.000009152151,0.000002921963,0.00009539539,6.865154e-7,0.9895892,0.0000116423,0.007355213,0.002219083],"study_design_scores_gemma":[0.000547589,0.0001770244,0.0001959846,0.00006397488,0.000003985236,0.00001138097,0.00005359404,0.00007902636,0.9831126,0.00008305083,0.01555638,0.0001153913],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979233,0.0009918591,0.0002051268,0.0001358308,0.00006629571,0.0001292665,0.00004930176,0.000009216576,0.000489856],"genre_scores_gemma":[0.9969464,0.0003620964,0.001030759,0.0001276823,0.00009643056,0.00001012492,0.0001843708,0.00001969592,0.001222453],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008201166,"threshold_uncertainty_score":0.4143968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00844782954142663,"score_gpt":0.2589333999014353,"score_spread":0.2504855703600087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}