{"id":"W1973585083","doi":"10.1038/onc.2010.366","title":"Suppression of Her2/neu expression through ILK inhibition is regulated by a pathway involving TWIST and YB-1","year":2010,"lang":"en","type":"article","venue":"Oncogene","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Drug Research and Development; BC Cancer Agency; Child and Family Research Institute; University of British Columbia","funders":"BC Cancer Agency; University of British Columbia; Canadian Breast Cancer Research Alliance","keywords":"Integrin-linked kinase; Gene silencing; Biology; Small interfering RNA; HER2/neu; Kinase; Molecular biology; Twist transcription factor; Cancer research; Cell culture; Cell biology; Protein kinase A; Transcription factor; Nuclear protein; Transfection; Biochemistry; Cancer; Breast cancer; Gene; Cyclin-dependent kinase 2; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009644494,0.0003216097,0.0002265063,0.0001336849,0.0001380467,0.0002284653,0.0000851838,0.0001107527,0.0009138602],"category_scores_gemma":[0.00006064781,0.00007143202,0.000192565,0.0001030772,0.0001544495,0.0001548979,0.0001133103,0.0004144408,0.000167713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002564894,"about_ca_system_score_gemma":0.0001599366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003089781,"about_ca_topic_score_gemma":0.0007541106,"domain_scores_codex":[0.9999267,0.00001098667,0.000006671655,0.00001125193,0.00001798876,0.00002636706],"domain_scores_gemma":[0.9999523,0.000008448525,0.00001864105,0.000003514243,0.000006410428,0.00001073891],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001115584,0.00002107245,0.0001383885,0.00002804005,0.000002669424,0.00002903592,0.000007782493,0.00003912517,0.998821,0.00003780023,0.00001708449,0.0007464555],"study_design_scores_gemma":[0.00001894539,0.0002434372,0.002689811,0.000003208745,0.0000087801,0.0001175421,0.00001770232,0.0006519799,0.9951897,0.00002060678,0.001035436,0.000002827382],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956011,0.001467573,0.00163793,0.00007810626,0.00001628063,0.00002311106,0.0001512594,0.00003772951,0.0009869928],"genre_scores_gemma":[0.9962904,0.0008539991,0.001266792,0.00003743079,0.000005072575,0.000030715,0.0002333562,0.000008303618,0.001273876],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009138602,"threshold_uncertainty_score":0.003057182,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00844782954142663,"score_gpt":0.2589333999014353,"score_spread":0.2504855703600087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}