{"id":"W1973588440","doi":"10.1007/s00280-013-2224-8","title":"A phase 2 study of intravenous panobinostat in patients with castration-resistant prostate cancer","year":2013,"lang":"en","type":"article","venue":"Cancer Chemotherapy and Pharmacology","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"National Cancer Institute; Novartis Pharmaceuticals Corporation","keywords":"Panobinostat; Medicine; Prostate cancer; Tolerability; Internal medicine; Oncology; Cancer; Clinical endpoint; Prostate-specific antigen; Phases of clinical research; Urology; Adverse effect; Chemotherapy; Clinical trial; Histone deacetylase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006042746,0.0001397081,0.0001878246,0.00006188092,0.00004425427,0.000009202691,0.00008557704,0.00006582644,0.0003094713],"category_scores_gemma":[0.000002489408,0.0001175289,0.00001562228,0.0001212078,0.0001267468,0.000008338941,0.00002220561,0.0001091511,9.166966e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004495453,"about_ca_system_score_gemma":0.0001534148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001108064,"about_ca_topic_score_gemma":0.0005474536,"domain_scores_codex":[0.9990619,0.00007887097,0.0002073381,0.0002953999,0.0001152251,0.0002412184],"domain_scores_gemma":[0.9995598,0.0000100966,0.00008745772,0.0001114766,0.0001548232,0.00007635388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003075481,0.002342849,0.03302781,0.00005075385,0.0001466862,0.000004059601,0.002121785,0.00005460544,0.9385572,4.803585e-7,0.001556993,0.01906128],"study_design_scores_gemma":[0.03435476,0.008250311,0.03972652,0.0000254571,0.00003246389,0.000001352108,0.0004435044,0.000044458,0.913573,0.000004418517,0.003263433,0.0002803235],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977581,0.0006647159,0.000002679798,0.0001696171,0.00008224276,0.001237611,0.00005231536,0.000004093728,0.00002866018],"genre_scores_gemma":[0.9984266,0.0005043217,0.00001666685,0.0002412475,0.00007358576,0.0005495962,0.00002539749,0.00002174503,0.0001408803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03127928,"threshold_uncertainty_score":0.4792688,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008602750773293795,"score_gpt":0.3132406636134182,"score_spread":0.3046379128401244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}