{"id":"W1973609430","doi":"10.1074/jbc.m113.528232","title":"5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) Effect on Glucose Production, but Not Energy Metabolism, Is Independent of Hepatic AMPK in Vivo","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; Vanderbilt University","keywords":"AMPK; Internal medicine; Endocrinology; Chemistry; Adenine nucleotide; AMP-activated protein kinase; Adenylate kinase; In vivo; Metabolism; Protein kinase A; Energy charge; Adenosine monophosphate; Carbohydrate metabolism; Biochemistry; Biology; Nucleotide; Phosphorylation; Adenosine; Enzyme; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000155416,0.0008569382,0.0005500721,0.00029832,0.00017363,0.0003229663,0.0002907978,0.0003942754,0.00172084],"category_scores_gemma":[0.0001135481,0.0002045439,0.0003186776,0.0002213573,0.0003655268,0.0002288302,0.0001575851,0.0009634725,0.000527794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002604709,"about_ca_system_score_gemma":0.0002070045,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004783625,"about_ca_topic_score_gemma":0.001176815,"domain_scores_codex":[0.9997836,0.00003576091,0.00002364421,0.00005143328,0.00005153742,0.00005417459],"domain_scores_gemma":[0.9998228,0.00002654101,0.00006755345,0.00002986438,0.00001604815,0.00003719774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007326427,0.00005442261,0.0001044147,0.00005269873,0.0000122691,0.00004767744,0.000005859688,0.00003480444,0.997802,0.00004700789,0.00004563845,0.001060621],"study_design_scores_gemma":[0.0000782943,0.001126454,0.00391945,0.00000890637,0.00003796912,0.000213273,0.00001412112,0.0003408736,0.9925004,0.00002452867,0.001729675,0.000006011255],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852483,0.006620055,0.003431989,0.0002020586,0.0001500397,0.00007007401,0.0008585427,0.0003277258,0.003091249],"genre_scores_gemma":[0.9889193,0.003626163,0.003743515,0.0001354601,0.00004432499,0.00009920079,0.001399276,0.00006447919,0.001968259],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00172084,"threshold_uncertainty_score":0.005756795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00927516120053414,"score_gpt":0.2288477572366291,"score_spread":0.219572596036095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}