{"id":"W1973658117","doi":"10.2174/1566523054065039","title":"Immune Responses to Adeno-Associated Virus Vectors","year":2005,"lang":"en","type":"review","venue":"Current Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":214,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Immunogenicity; Immune system; Adeno-associated virus; Genetic enhancement; Vector (molecular biology); Biology; Transgene; Viral vector; Virology; Immunology; Capsid; Vectors in gene therapy; Antigen; Acquired immune system; Immunity; Humoral immunity; Antibody; Virus; Gene; Genetics; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008937216,0.0009186569,0.001469432,0.0004040312,0.0001990499,0.00009312649,0.001346023,0.0005990586,0.0002947311],"category_scores_gemma":[0.0001593401,0.0008041669,0.0009884207,0.0006488943,0.0001090368,0.000004728202,0.0002811047,0.0006001749,0.0005573079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00023507,"about_ca_system_score_gemma":0.0009737635,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001025139,"about_ca_topic_score_gemma":0.00005039555,"domain_scores_codex":[0.9954374,0.00107345,0.0008583518,0.001131177,0.0005413652,0.0009582262],"domain_scores_gemma":[0.9975055,0.00007334826,0.0003616607,0.001505741,0.0001951517,0.0003586061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001288499,0.0003324583,0.000002862494,0.0002148783,0.0005414278,0.000004282495,0.00003805186,0.000003711499,0.02741282,9.956137e-7,0.003459346,0.9667007],"study_design_scores_gemma":[0.0007068521,0.00252105,0.0000133461,0.0008178386,0.00009113843,0.00001068156,0.000002708477,5.667611e-7,0.02373289,0.000003528347,0.9712541,0.0008453233],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01788411,0.9790022,0.00001793848,0.00004482286,0.0008278587,0.001666454,0.0004395054,0.00006946558,0.0000476156],"genre_scores_gemma":[0.0002163563,0.9944006,0.00003903417,0.0001299875,0.001510104,0.0005070331,0.001509793,0.0002668025,0.00142029],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9677947,"threshold_uncertainty_score":0.9994409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0924212653901264,"score_gpt":0.4158482754005711,"score_spread":0.3234270100104447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}