{"id":"W1973658117","doi":"10.2174/1566523054065039","title":"Immune Responses to Adeno-Associated Virus Vectors","year":2005,"lang":"en","type":"review","venue":"Current Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":214,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Immunogenicity; Immune system; Adeno-associated virus; Genetic enhancement; Vector (molecular biology); Biology; Transgene; Viral vector; Virology; Immunology; Capsid; Vectors in gene therapy; Antigen; Acquired immune system; Immunity; Humoral immunity; Antibody; Virus; Gene; Genetics; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003083548,0.0007006173,0.000832238,0.000929311,0.0002037964,0.0007169279,0.0006608409,0.0007782232,0.002546665],"category_scores_gemma":[0.0002886546,0.000165525,0.0002606413,0.0008476889,0.0003641404,0.0005972579,0.0002971831,0.0008415827,0.003171267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005539002,"about_ca_system_score_gemma":0.0003835842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003951461,"about_ca_topic_score_gemma":0.0004243715,"domain_scores_codex":[0.9997974,0.00003004055,0.00001688181,0.00003430843,0.0001068426,0.00001449509],"domain_scores_gemma":[0.999891,0.00004587002,0.00001812475,0.000004403785,0.00003003906,0.00001052633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007650001,0.0000912107,0.0002575769,0.008951993,0.00004279707,0.0006933662,0.00009930502,0.0005158585,0.0511127,0.006037414,0.0151509,0.9169704],"study_design_scores_gemma":[0.00001419195,0.0001631193,0.0010525,0.0008651408,0.0000372192,0.002757852,0.00004890128,0.000115506,0.01336895,0.001694277,0.9798663,0.00001607799],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001478838,0.9862339,0.002335707,0.0003428648,0.0005365469,0.00002304034,0.00003043507,0.00006091077,0.008957796],"genre_scores_gemma":[0.004521469,0.9860942,0.00136583,0.0003729808,0.0002014729,0.00003500636,0.00007179893,0.000006796837,0.007330402],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002546665,"threshold_uncertainty_score":0.008519471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0924212653901264,"score_gpt":0.4158482754005711,"score_spread":0.3234270100104447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}