{"id":"W1973683234","doi":"10.1056/nejmoa070608","title":"Clinical Outcomes of Breast Cancer in Carriers of <i>BRCA1</i> and <i>BRCA2</i> Mutations","year":2007,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":299,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's College Hospital; University of Toronto","funders":"National Cancer Institute","keywords":"Medicine; Breast cancer; Oncology; Mutation; BRCA2 Protein; Internal medicine; Cancer; Population; Gynecology; Germline mutation; Genetics; Gene; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000775565,0.0002279218,0.0002653985,0.0006326444,0.0003677867,0.0004591903,0.0003223415,0.0004686203,0.001147548],"category_scores_gemma":[0.003205048,0.0001827363,0.0002349964,0.0004288872,0.0003960108,0.0003011884,0.0003590562,0.0004084963,0.0001609376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003282596,"about_ca_system_score_gemma":0.0002765368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002481365,"about_ca_topic_score_gemma":0.002006866,"domain_scores_codex":[0.9996501,0.0001138321,0.00002563052,0.00007203656,0.00005520634,0.00008325651],"domain_scores_gemma":[0.9979967,0.0004221455,0.0009484421,0.00007097131,0.0001412082,0.0004204113],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002008777,0.0000239632,0.9987586,0.000003414953,0.00001966994,0.0001366927,0.00002485843,0.00003034061,0.00008045932,0.000008433885,0.00005573855,0.000657045],"study_design_scores_gemma":[0.00001774427,0.0001436753,0.998847,0.00000409344,0.00002520937,0.0006324087,0.00007566753,0.0001168462,0.0000398334,0.0000349867,0.00005936614,0.000003170589],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995674,0.0001258358,0.00001465188,0.00003679041,0.000002998034,0.000002731058,0.0000878433,0.000001211443,0.0001605621],"genre_scores_gemma":[0.9996386,0.00005503942,0.00001765734,0.00001234108,0.00000998026,0.000003813194,0.0002064757,7.11259e-7,0.00005544191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002481365,"threshold_uncertainty_score":0.004933774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01479213713450472,"score_gpt":0.3410675326988085,"score_spread":0.3262753955643038,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}