{"id":"W1973698406","doi":"10.1002/ana.22060","title":"Initiating levodopa/carbidopa therapy with and without entacapone in early Parkinson disease: The STRIDE‐PD study","year":2010,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":370,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Novartis Pharma; Novartis","keywords":"Entacapone; Dyskinesia; Medicine; Carbidopa; Catechol-O-methyl transferase; Parkinson's disease; Levodopa; Internal medicine; Hazard ratio; Anesthesia; Randomized controlled trial; Clinical endpoint; Disease; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001951588,0.001012956,0.003152765,0.0003224181,0.0003620352,0.0008753784,0.0007280559,0.001318925,0.001985369],"category_scores_gemma":[0.001632717,0.0005614576,0.00220955,0.000385098,0.0007037772,0.0005334525,0.0004296461,0.002208317,0.0002977202],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006625225,"about_ca_system_score_gemma":0.001253783,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001263349,"about_ca_topic_score_gemma":0.002556869,"domain_scores_codex":[0.9991709,0.0004218513,0.00005481827,0.0001389242,0.0001020023,0.0001115706],"domain_scores_gemma":[0.9983815,0.0004569728,0.0003403694,0.0001340019,0.00007721782,0.0006098407],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9516152,0.01398337,0.01371315,0.0003308615,0.001815914,0.00007397141,0.00006052272,0.000264821,0.002528017,0.0000435138,0.0002220663,0.01534858],"study_design_scores_gemma":[0.6496775,0.2691402,0.07557515,0.00009446188,0.002981538,0.0001348945,0.00006264687,0.0007659397,0.0006616283,0.0001019051,0.0007713782,0.00003295288],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997386,0.001681112,0.00006465946,0.0000756185,0.00004398451,0.0001892874,0.0002269426,0.000008298729,0.00032398],"genre_scores_gemma":[0.9958967,0.001643224,0.0003200935,0.0002810391,0.0001721902,0.0002898662,0.0006845509,0.000004442168,0.0007080357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003152765,"threshold_uncertainty_score":0.01032114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0546320849694284,"score_gpt":0.3273075309724409,"score_spread":0.2726754460030125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}