{"id":"W1973704482","doi":"10.1371/journal.pone.0029996","title":"Site-Directed Mutations and the Polymorphic Variant Ala160Thr in the Human Thromboxane Receptor Uncover a Structural Role for Transmembrane Helix 4","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital Research Institute of Manitoba; University of Manitoba","funders":"National Institutes of Health; Manitoba Medical Service Foundation; Manitoba Health Research Council; National Heart, Lung, and Blood Institute; Heart and Stroke Foundation of Canada; American Heart Association","keywords":"Transmembrane domain; G protein-coupled receptor; Mutant; Helix (gastropod); Biology; Genetics; Receptor; Transmembrane protein; Mutation; Subfamily; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001580664,0.0003232435,0.0002098853,0.0001236749,0.0001509931,0.0001972275,0.0002558856,0.0004428553,0.001156177],"category_scores_gemma":[0.0001825449,0.0001332745,0.0004577774,0.0001413241,0.0002604701,0.00009559815,0.0001915103,0.0006181267,0.0005764856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001958052,"about_ca_system_score_gemma":0.0001678356,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005556163,"about_ca_topic_score_gemma":0.0005997028,"domain_scores_codex":[0.9998791,0.00002985934,0.00002023944,0.00002242003,0.00003195327,0.00001633239],"domain_scores_gemma":[0.9999014,0.00002979202,0.00003306992,0.00001180727,0.00000807688,0.00001588896],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004547793,0.00006656098,0.0007100654,0.00003515718,0.00002525845,0.0006843554,0.00003079923,0.0004657882,0.9948953,0.0001976586,0.00008729473,0.002346927],"study_design_scores_gemma":[0.0001843982,0.001204546,0.01061224,0.00002688612,0.000112911,0.00560985,0.0001012161,0.005984396,0.9709787,0.0002214005,0.004931172,0.00003235048],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979607,0.000285379,0.001038941,0.00005975792,0.00002820442,0.0000205792,0.0002049534,0.00002065143,0.000380792],"genre_scores_gemma":[0.9967383,0.0002213081,0.001879064,0.00007109358,0.00001293143,0.00001549508,0.0003269796,0.00001523564,0.0007195175],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001156177,"threshold_uncertainty_score":0.003867805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02005923753592494,"score_gpt":0.2329355242298993,"score_spread":0.2128762866939744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}