{"id":"W1973708763","doi":"10.1097/cji.0000000000000022","title":"Targeted siRNA Silencing of Indoleamine 2, 3-Dioxygenase in Antigen-presenting Cells Using Mannose-conjugated Liposomes","year":2014,"lang":"en","type":"article","venue":"Journal of Immunotherapy","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University; Cancer Care Ontario","funders":"Canadian Institutes of Health Research","keywords":"Indoleamine 2,3-dioxygenase; Immune system; Cancer research; Spleen; Small interfering RNA; Immunology; FOXP3; Antigen; Gene silencing; Antigen-presenting cell; T cell; Biology; Transfection; Cell culture","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001412078,0.0003372816,0.000224365,0.0001210091,0.00009037109,0.0002430557,0.0001656804,0.0002356033,0.0003603892],"category_scores_gemma":[0.00007206552,0.0001189748,0.0002470955,0.00009023857,0.0001852399,0.0001713092,0.0001605218,0.0003417479,0.0001554262],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002742284,"about_ca_system_score_gemma":0.0002280818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004168697,"about_ca_topic_score_gemma":0.0005130952,"domain_scores_codex":[0.9999081,0.00001157126,0.00001365553,0.00002720284,0.00002045183,0.00001887136],"domain_scores_gemma":[0.999947,0.00001042825,0.00002143912,0.000005500373,0.000006204042,0.000009514493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002319243,0.000007155407,0.00003871328,0.00001842196,0.000002065361,0.00001233788,0.000006594964,0.00004822492,0.9992477,0.00007755194,0.0000098136,0.0005082259],"study_design_scores_gemma":[0.00001032552,0.0001211202,0.0004712855,0.000001987468,0.00001095372,0.00004071815,0.000005897935,0.0009406967,0.9975165,0.00001643885,0.0008615361,0.000002515399],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831875,0.001198018,0.0138408,0.00008381687,0.00004501553,0.00009608524,0.0002214816,0.0001253849,0.001201981],"genre_scores_gemma":[0.991293,0.0008053533,0.005976419,0.00004200826,0.0000108462,0.00008973786,0.0002020071,0.00001631776,0.001564247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004168697,"threshold_uncertainty_score":0.001989663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01219792477443848,"score_gpt":0.2486350573814467,"score_spread":0.2364371326070082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}