{"id":"W1973717399","doi":"10.1016/j.cardiores.2006.05.015","title":"Estradiol blocks the induction of CD40 and CD40L expression on endothelial cells and prevents neutrophil adhesion: An ERα-mediated pathway","year":2006,"lang":"en","type":"article","venue":"Cardiovascular Research","topic":"Atherosclerosis and Cardiovascular Diseases","field":"Immunology and Microbiology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute; Université de Montréal","funders":"Canadian Institutes of Health Research; Institut de Cardiologie de Montréal","keywords":"CD40; STAT1; Phosphorylation; Cell biology; Signal transduction; STAT protein; STAT3; Interferon gamma; Chemistry; Biology; Cancer research; Molecular biology; Cytokine; Immunology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001947474,0.0002193145,0.0004716891,0.0001429544,0.0004726018,0.0000451034,0.0002641951,0.0002830395,0.00004086278],"category_scores_gemma":[0.00007274908,0.0001501882,0.0004906011,0.000210906,0.0006932099,0.0001082571,0.0001656774,0.000519147,0.00002153099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000031856,"about_ca_system_score_gemma":0.00006781847,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002296869,"about_ca_topic_score_gemma":0.000003164047,"domain_scores_codex":[0.9964315,0.001891701,0.0002784759,0.0005831498,0.0003729751,0.0004422177],"domain_scores_gemma":[0.9986054,0.0001891991,0.00006088682,0.0009235726,0.0001528961,0.0000680127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000192053,0.0002269478,0.0006896041,0.0000458002,0.0006440007,0.00001362343,0.0001618305,0.0001099483,0.9750925,0.0001020715,0.0005816244,0.02213994],"study_design_scores_gemma":[0.003495382,0.0006829742,0.06776511,0.0001838207,0.0002569105,0.0001015975,0.0006657231,0.00001010714,0.8902701,0.0002446257,0.03599438,0.0003292647],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9724178,0.02625887,0.00002685103,0.00003099897,0.0002046789,0.0006435997,0.0001013303,0.00003363011,0.0002822671],"genre_scores_gemma":[0.9974667,0.001884965,0.00001462415,0.00001211421,0.0002071784,0.00008548029,0.00007202355,0.00003296022,0.0002239835],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08482245,"threshold_uncertainty_score":0.6124496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03251943106511321,"score_gpt":0.2584653987299634,"score_spread":0.2259459676648502,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}