{"id":"W1973732930","doi":"10.3892/ijo.2014.2626","title":"Postnatal Notch1 activation induces T-cell malignancy in conditional and inducible mouse models","year":2014,"lang":"en","type":"article","venue":"International Journal of Oncology","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre","funders":"Heart and Stroke Foundation of Canada","keywords":"Biology; Transgene; Genetically modified mouse; Cancer research; Haematopoiesis; Embryonic stem cell; Cre recombinase; Cell biology; Molecular biology; T cell; Immunology; Stem cell; Immune system; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003030038,0.00007533152,0.0001120724,0.0001453107,0.00002177674,0.00001047696,0.0001421172,0.0001719928,0.00001505218],"category_scores_gemma":[0.00005888927,0.00007069638,0.0000325388,0.0000322257,0.0000585026,0.00002708118,0.00005968944,0.000109715,0.000002302158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004918082,"about_ca_system_score_gemma":0.0001513061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007380709,"about_ca_topic_score_gemma":0.00001415737,"domain_scores_codex":[0.9993067,0.00007668547,0.0002797424,0.0001272741,0.00012177,0.00008781241],"domain_scores_gemma":[0.9994712,0.00003213373,0.0002285108,0.00004498584,0.0001852321,0.00003786244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004050572,0.0001996152,0.008038345,0.000004135327,0.00007061826,0.00001444286,0.0001274986,0.0009543637,0.9739604,0.001449145,0.000546143,0.01423024],"study_design_scores_gemma":[0.00343157,0.001091925,0.05736716,0.0000306991,0.000009761146,0.0006193435,0.0001362148,0.0003148715,0.9181088,0.005039684,0.01364185,0.0002080787],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949641,0.00008269241,0.002203463,0.0007044686,0.0003038789,0.00004365284,0.000007202278,0.00000161002,0.001688952],"genre_scores_gemma":[0.9977708,0.0001048212,0.001151699,0.0004486171,0.0002368916,0.000002940333,0.0001190945,0.000005547852,0.0001595902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05585156,"threshold_uncertainty_score":0.2882915,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01191226595898392,"score_gpt":0.275608978436479,"score_spread":0.263696712477495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}