{"id":"W1973740519","doi":"10.1155/2010/150960","title":"Clinical Relevance of KRAS in Human Cancers","year":2010,"lang":"en","type":"review","venue":"Journal of Biomedicine and Biotechnology","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":400,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Ministerstvo Zdravotnictví Ceské Republiky","keywords":"KRAS; Oncogene; Cancer research; Viral Oncogene; Carcinogenesis; Biology; Cancer; Gene; Mutation; Genetics; Cell cycle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0008263463,0.0001898357,0.001226317,0.0004998048,0.00002042351,0.000002914192,0.0002458912,0.001331985,0.000007347826],"category_scores_gemma":[0.0002645208,0.0001336961,0.0002380067,0.0002709185,0.0005567438,0.000002434823,0.0000889296,0.0007769573,3.371194e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002026396,"about_ca_system_score_gemma":0.0003099285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000121943,"about_ca_topic_score_gemma":0.0000256653,"domain_scores_codex":[0.9981363,0.00008436487,0.001286885,0.0002200156,0.0001175256,0.0001548489],"domain_scores_gemma":[0.9983163,0.00003256646,0.00124928,0.0002466917,0.00008523694,0.00006991232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001952996,0.0000401471,0.00003774897,0.001023764,0.00007271732,0.00003471628,0.000002919948,1.105717e-7,0.03060593,0.00007670413,0.0002215521,0.9678642],"study_design_scores_gemma":[0.0006180532,0.0009833697,0.00001561947,0.003495919,0.000140767,0.0003451362,0.00001272184,8.809915e-7,0.004237661,0.00006925595,0.9899551,0.0001254846],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.008432696,0.9907658,0.0001395014,0.0002063009,0.0002568121,0.0001588367,0.000008543175,0.000003032276,0.000028549],"genre_scores_gemma":[0.003932969,0.994821,0.0006840428,0.00004226855,0.000445136,0.000002525108,0.00001911741,0.0000157456,0.00003725678],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9897336,"threshold_uncertainty_score":0.9999645,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02814852495779308,"score_gpt":0.3689767417107445,"score_spread":0.3408282167529514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}