{"id":"W1973740519","doi":"10.1155/2010/150960","title":"Clinical Relevance of KRAS in Human Cancers","year":2010,"lang":"en","type":"review","venue":"Journal of Biomedicine and Biotechnology","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":400,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Ministerstvo Zdravotnictví Ceské Republiky","keywords":"KRAS; Oncogene; Cancer research; Viral Oncogene; Carcinogenesis; Biology; Cancer; Gene; Mutation; Genetics; Cell cycle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000533146,0.0005132254,0.001096051,0.001411195,0.000179154,0.0006734103,0.0004802853,0.001040454,0.002147506],"category_scores_gemma":[0.0008028027,0.0001603689,0.0002530965,0.001169736,0.0004804568,0.0006323188,0.0004616212,0.001267518,0.002158203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004484849,"about_ca_system_score_gemma":0.0006864449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006208734,"about_ca_topic_score_gemma":0.001008033,"domain_scores_codex":[0.9997619,0.00005768402,0.00003182462,0.00004576876,0.00008715404,0.00001572599],"domain_scores_gemma":[0.9997136,0.0001400984,0.00003766532,0.000009779917,0.00007445645,0.00002441325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000728316,0.00002852105,0.0006237765,0.004861327,0.00004467124,0.0009914179,0.0000599779,0.0002315237,0.002627591,0.003636372,0.02373948,0.9630824],"study_design_scores_gemma":[0.00002123696,0.00008125368,0.002486471,0.002018725,0.00006489987,0.01113624,0.000066431,0.00008861138,0.001450733,0.002315194,0.9802506,0.00001972236],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002377845,0.9969975,0.0002213807,0.0005085913,0.0002019429,0.000003262036,0.00001257353,0.000006902768,0.001810139],"genre_scores_gemma":[0.003292163,0.9940818,0.0003347973,0.0004007505,0.0004503111,0.000007401791,0.00004122332,0.000002846844,0.001388788],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002147506,"threshold_uncertainty_score":0.007184088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02814852495779308,"score_gpt":0.3689767417107445,"score_spread":0.3408282167529514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}