{"id":"W1973740991","doi":"10.1074/jbc.m114.601096","title":"Adipocyte Lipolysis-stimulated Interleukin-6 Production Requires Sphingosine Kinase 1 Activity","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Lipolysis; Adipocyte; Endocrinology; Internal medicine; Sphingosine; Sphingosine kinase; Biology; Sphingosine kinase 1; Lipid signaling; Adipose tissue; Hormone-sensitive lipase; Sphingosine-1-phosphate; Cell biology; Inflammation; Receptor; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006666328,0.000202551,0.0003431801,0.00003254598,0.0000766759,0.00003167781,0.0002901606,0.0002837358,0.00008286211],"category_scores_gemma":[0.001481059,0.0001466936,0.0002438316,0.0001146055,0.0001238322,0.00001198402,0.0001007902,0.0002918994,0.000004389591],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002266327,"about_ca_system_score_gemma":0.00004640437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003955663,"about_ca_topic_score_gemma":4.986007e-7,"domain_scores_codex":[0.9987598,0.00009587705,0.0004226953,0.0003032011,0.0001705585,0.0002478512],"domain_scores_gemma":[0.9988695,0.00003232005,0.0004457725,0.0002793781,0.0002145502,0.0001585003],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004783523,0.000115128,0.001048528,0.00002431403,0.00007302568,0.00000606467,0.00001323871,0.0001630945,0.9922349,0.000003837327,0.0004604744,0.005379062],"study_design_scores_gemma":[0.0005515011,0.0002565972,0.002049806,0.00004227152,0.00004430934,0.0001560659,0.00001664124,0.00008215437,0.9760823,0.00007346351,0.02046226,0.000182681],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972473,0.0006825165,0.001189044,0.0001710763,0.0003463173,0.00004791254,0.000003374788,0.00001452007,0.0002978865],"genre_scores_gemma":[0.9961774,0.0002128387,0.000550532,0.000120858,0.002692387,0.000002129744,0.00001901234,0.00001427118,0.0002105147],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02000179,"threshold_uncertainty_score":0.5981991,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01749422941759317,"score_gpt":0.2553358731399898,"score_spread":0.2378416437223966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}