{"id":"W1973776098","doi":"10.1371/journal.pgen.1004933","title":"hnRNP K Coordinates Transcriptional Silencing by SETDB1 in Embryonic Stem Cells","year":2015,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Universidad de Buenos Aires; Genome Institute of Singapore; Michael Smith Health Research BC; Natural Sciences and Engineering Research Council of Canada; RWTH Aachen University; University of Washington","keywords":"Biology; Gene silencing; Chromatin; Endogenous retrovirus; Gene knockdown; Embryonic stem cell; RNA interference; Repressor; Genetics; Molecular biology; Cell biology; Transcription factor; Gene; RNA; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001332579,0.000275946,0.0002671171,0.0002581171,0.0001632711,0.0004786692,0.0003922152,0.0002195247,0.001241842],"category_scores_gemma":[0.0001399332,0.0002686849,0.0002193097,0.0001850549,0.0002793387,0.00014469,0.0005048559,0.0004711104,0.0006110898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000607838,"about_ca_system_score_gemma":0.0002599868,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008234183,"about_ca_topic_score_gemma":0.001950298,"domain_scores_codex":[0.9997671,0.00003183979,0.00003346476,0.00005689713,0.00007808329,0.00003256263],"domain_scores_gemma":[0.9998648,0.00002682843,0.00004199937,0.00002377497,0.00001147733,0.00003111659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002280774,0.000003373044,0.0001073876,0.000009003968,0.00000201143,0.0000218035,0.000006119454,0.00006107237,0.9993578,0.00007392091,0.00001128372,0.0003235252],"study_design_scores_gemma":[0.000005257848,0.00002577503,0.002678037,0.000001962984,0.000005770174,0.0001032291,0.00001279992,0.0009529872,0.9953007,0.00004005248,0.000870698,0.000002764138],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900104,0.0008726497,0.005859067,0.00006162251,0.00001991614,0.0000242432,0.000725099,0.0002256617,0.002201284],"genre_scores_gemma":[0.9927059,0.0003752149,0.003114246,0.00003724372,0.000003585478,0.00002107699,0.0006489455,0.0000571645,0.003036592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001241842,"threshold_uncertainty_score":0.004410148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01741670453844386,"score_gpt":0.259362698291663,"score_spread":0.2419459937532191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}