{"id":"W1973803211","doi":"10.1074/jbc.m110.144261","title":"Cell Surface Rescue of Kidney Anion Exchanger 1 Mutants by Disruption of Chaperone Interactions","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; National Institutes of Health; Canadian Institutes of Health Research; Hospital for Sick Children; University of Toronto; University of Pittsburgh","keywords":"Calnexin; Endoplasmic reticulum; Endoplasmic-reticulum-associated protein degradation; Golgi apparatus; Cell biology; Mutant; Biology; Distal renal tubular acidosis; Chaperone (clinical); Cell membrane; Transport protein; Membrane protein; Chemistry; Biochemistry; Unfolded protein response; Cell; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000131833,0.0004423066,0.0002765995,0.0001583565,0.0001679039,0.0003224703,0.0002749948,0.0003230319,0.0007728132],"category_scores_gemma":[0.0001045318,0.0001632311,0.0002487838,0.00011328,0.0002096423,0.0001441308,0.0003268814,0.0005577022,0.0005434692],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002684759,"about_ca_system_score_gemma":0.0001983375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000670812,"about_ca_topic_score_gemma":0.0008720015,"domain_scores_codex":[0.999851,0.00002682478,0.0000239487,0.00002334016,0.00004401511,0.00003092688],"domain_scores_gemma":[0.9998751,0.00001868916,0.00004478071,0.000018877,0.0000121412,0.00003036057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003390076,0.0000131645,0.00005660511,0.00001066086,0.000003365268,0.00006156956,0.00000759409,0.00005599689,0.9993852,0.00006517763,0.00002069271,0.0002858955],"study_design_scores_gemma":[0.00002190876,0.0001207817,0.001938829,0.000004138932,0.00001247628,0.0004496142,0.00002787532,0.001081686,0.9940253,0.0000361017,0.002276113,0.000005253049],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965616,0.0004494496,0.00174057,0.00009815641,0.00002605349,0.00001356563,0.000319329,0.00007704539,0.0007143288],"genre_scores_gemma":[0.9950503,0.0004244674,0.001528242,0.00004386204,0.000005878294,0.00001786585,0.0006650973,0.00004731617,0.002216864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007728132,"threshold_uncertainty_score":0.002585292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01171124665946038,"score_gpt":0.2482222486104969,"score_spread":0.2365110019510365,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}