{"id":"W1973836742","doi":"10.1158/1538-7445.am10-lb-296","title":"Abstract LB-296: Synergistic anticancer action of inhibitor of DNA methylation 5-aza-2-deocycytidine and EZH2 histone methylase inhibitor 3-deazaneplanocin A","year":2010,"lang":"en","type":"article","venue":"Cancer Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"EZH2; Biology; Epigenetics; DNA methylation; Methyltransferase; Cancer research; Carcinogenesis; Methylation; Epigenetic therapy; Molecular biology; Histone methyltransferase; PRC2; DNA; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007980288,0.0002711215,0.0003702205,0.0002459276,0.00009252687,0.0001743454,0.0002074979,0.0001744302,0.00181831],"category_scores_gemma":[0.00006947717,0.00007321329,0.0001545003,0.0001643311,0.0000977427,0.00009615108,0.0001615045,0.000381176,0.0002867141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001468449,"about_ca_system_score_gemma":0.000211681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007391506,"about_ca_topic_score_gemma":0.001057574,"domain_scores_codex":[0.9999161,0.00001944613,0.000007009339,0.00001189714,0.0000207115,0.00002481238],"domain_scores_gemma":[0.9999584,0.000007932359,0.000006243978,0.000003750735,0.000004457797,0.00001936056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001127706,0.000252369,0.0002759138,0.00008930205,0.0000186466,0.0001179641,0.000009469503,0.0002649798,0.99073,0.0001041854,0.0001999797,0.006809437],"study_design_scores_gemma":[0.000200727,0.003506666,0.003989972,0.00001013773,0.00004531668,0.0004449359,0.00001999676,0.001357408,0.9861602,0.0000367,0.004220609,0.000007439196],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893756,0.004347701,0.001346992,0.000114339,0.00006504212,0.0000927684,0.0004330226,0.0001212272,0.004103347],"genre_scores_gemma":[0.9954425,0.001158756,0.00114573,0.00005099255,0.00001314189,0.00003950675,0.00050208,0.00000825895,0.001638975],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00181831,"threshold_uncertainty_score":0.006082833,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05095738796661584,"score_gpt":0.4057045201538518,"score_spread":0.3547471321872359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}