{"id":"W1973858241","doi":"10.1111/acel.12020","title":"Enforcement of a lifespan‐sustaining distribution of Sir2 between telomeres, mating‐type loci, and <scp>rDNA</scp> repeats by Rif1","year":2012,"lang":"en","type":"article","venue":"Aging Cell","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Biology; Genetics; Telomere; Sirtuin; Histone deacetylase; Histone; Chromatin; Genome instability; SIRT2; Telomere-binding protein; Saccharomyces cerevisiae; Cell biology; Gene; DNA damage; DNA; Acetylation; DNA-binding protein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001132932,0.000330341,0.0002049692,0.0001175956,0.0001102106,0.0002709277,0.000229605,0.0001806613,0.0009622419],"category_scores_gemma":[0.00009555541,0.0001373565,0.0002088393,0.00007244662,0.0001484324,0.0001476798,0.0002375546,0.0003424782,0.0003853016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002188242,"about_ca_system_score_gemma":0.0001468097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002733321,"about_ca_topic_score_gemma":0.0004807908,"domain_scores_codex":[0.9999107,0.00001139561,0.000008533684,0.00002913771,0.00002493341,0.0000152876],"domain_scores_gemma":[0.9998603,0.00001418206,0.0000638953,0.00001868839,0.00001236542,0.00003059853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002389878,0.000002582427,0.0001194585,0.00001207755,0.000001713678,0.0000161086,0.00000305389,0.00002046029,0.999415,0.00002292189,0.000009003685,0.0003536269],"study_design_scores_gemma":[0.000004829782,0.00005362424,0.005438117,0.000003482612,0.000005671051,0.0001890144,0.00001249766,0.000605159,0.9923099,0.00002303571,0.001351304,0.000003263077],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922292,0.001927355,0.004281862,0.00006080837,0.00002052607,0.000007376668,0.0004143787,0.0001422321,0.0009163636],"genre_scores_gemma":[0.994991,0.0006068039,0.002052707,0.00002889966,0.000007362399,0.00001124434,0.0007070529,0.00003178584,0.001563226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009622419,"threshold_uncertainty_score":0.003218949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01367013319474235,"score_gpt":0.2702243453449002,"score_spread":0.2565542121501578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}